Evidence map›Paper›PMID 40566643›Full record

ArticleThe Journal of physiology2025

Parkinson's disease-linked Kir4.2 mutation R28C leads to loss of ion channel function.

Xiaoyi Chen, Rocio K Finol-Urdaneta, Mo Chen, Alex M Sykes, Bingmiao Gao, Jamila Iqbal, David J Adams, George D Mellick, Linlin Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoyi ChenInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
Rocio K Finol-UrdanetaSchool of Medical, Indigenous and Health Sciences, Molecular Horizons, University of Wollongong, New South Wales, Australia.ORCID 0000-0003-2157-4532
Mo ChenInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
Alex M SykesInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.ORCID 0000-0001-8981-6652
Bingmiao GaoEngineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, China.
Jamila IqbalInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
David J AdamsSchool of Medical, Indigenous and Health Sciences, Molecular Horizons, University of Wollongong, New South Wales, Australia.ORCID 0000-0002-7030-2288
George D MellickInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
Linlin MaInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.ORCID 0000-0002-4716-5158

Funding

Michael J Fox Foundation MJFF-021285NHMRC 2021 Genomics Health Futures Mission Stream 1 2016760NSW Health Cardiovascular Disease Senior Researcher Grant
6 · The paper itself

Abstract

Parkinson's disease (PD) is a complex, progressive neurodegenerative disorder driven by multiple pathogenetic factors, including oxidative stress, mitochondria dysfunction, neuroinflammation and ion imbalance. Recent evidence highlights the significant role of potassium channels in the pathophysiology of PD. We recently identified a PD-linked genetic mutation in the KCNJ15 gene (KCNJ15

Indexed as

Parkinson DiseasePotassium Channels, Inwardly RectifyingCell MembraneEndoplasmic ReticulumHEK293 CellsHumansMutationPotassium Channels, Inwardly Rectifyinggenetic mutationinwardly rectifying potassium channelKir4.2Parkinson's disease

Identifiers

PMID40566643
PMCPMC12206441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.