ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- An interpretable nomogram for predicting sleep disturbance risk in maintenance hemodialysis patients.International urology and nephrology · 2026Article
- Prediction of cognitive performance by demographics, sleep, and brain morphometry: machine learning findings from ENIGMA-Sleep Working Group.Research square · 2026Article
- Alzheimer's disease as a systems-level timing disorder: Circadian disruption of glial immunometabolism, brain clearance, and therapeutic responsiveness.Neurobiology of sleep and circadian rhythms · 2026Review
- Glial cytokine modulation improves sleep and circadian disruption in female SAA knock-in mice of Alzheimer's-related pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multidimensional self-reported sleep health, cognitive decline, and risk of all-cause dementia: A population-based multi-cohort study.Journal of Alzheimer's disease : JAD · 2026Article
- Sleep and neurocognitive performance in middle-aged Latina women in a rural agricultural community: insights from the CHAMACOS Maternal Cognition Study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Subjective sleep characteristics in non-demented adults: domain-specific associations with multimodal Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Abstract
introductionSleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical thickness (CTh), but associations with objective sleep measures, particularly regarding sex and AD pathology, remain unclear.
methodsWe characterized 171 cognitively unimpaired adults from the ALzheimer and FAmilies (ALFA) Sleep study using actigraphy, MRI, amyloid beta 42/40, and phosphorylated tau at threonine 181 in cerebrospinal fluid.
resultsLower sleep efficiency, higher wake after sleep onset (WASO), and sleep fragmentation were associated with lower CTh in the medial temporal lobe and other regions linked with AD and sleep disruption, even after adjusting for AD biomarkers. Sex and AD biomarkers modified these associations, with longer WASO showing a stronger correlation with lower CTh in females. DISCUSSION: Disrupted sleep may reduce cortical integrity independently of AD biomarkers, suggesting alternative pathways. Females appear more vulnerable to impaired sleep, and AD pathology may exacerbate AD-related changes in CTh. HIGHLIGHTS: Poor sleep efficiency, increased WASO, and sleep fragmentation are associated with reduced CTh in regions vulnerable to early AD, independently of amyloid and tau pathology. In the presence of AD pathology, this relationship is altered, with A+T+ individuals exhibiting increased CTh associated with sleep disruption. Sex-specific effects suggest females are more vulnerable to sleep-related cortical thinning. These findings highlight the potential of targeting sleep as a secondary prevention strategy to preserve brain integrity and mitigate neurodegenerative processes in AD-vulnerable regions.
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