Evidence mapPaperPMID 40566793Full record

ArticleDiabetes, obesity & metabolism2025

Glycaemic impact of the pre-exercise timing of an elevated glucose target implemented using an automated insulin delivery system in adults with type 1 diabetes.

Dale J Morrison, Sara Vogrin, Dessi P Zaharieva, Georgina Manos, Bella Halim, David O'Neal

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Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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2 citing papers in PubMed.

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5 · Who and what money

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6 authors.

Dale J MorrisonDepartment of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-3613-4946
Sara VogrinDepartment of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
Dessi P ZaharievaDivision of Pediatric Endocrinology, Department of Pediatrics, Stanford University, Stanford, California, USA.
Georgina ManosDepartment of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
Bella HalimDepartment of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
David O'NealDepartment of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-0870-4032

Funding

Medtronic
6 · The paper itself

Abstract

aimTo determine the impact of a temporary elevated glucose target (TT) on hypoglycaemia and glycaemic outcomes with exercise in adults with type 1 diabetes using an automated insulin delivery (AID) system. MATERIALS AND

methodsTwenty-six participants using the Medtronic MiniMed™ 780G system performed 16 exercise bouts: 12 afternoon bouts (four 40 min and four 90 min moderate-intensity exercise [MIE] and four 40 min high-intensity interval exercise [HIE]) and four morning bouts of 40 min MIE, with a TT set 60 min (TT60), 20 min (TT20), 0 min (TT0) or no TT (TTnil) pre-exercise. Oral carbohydrate was consumed pre-exercise for glucose <100 mg/dL and during exercise for sensor glucose <70 mg/dL or symptomatic hypoglycaemia confirmed by fingerprick blood glucose. The primary outcome was time below range (TBR; <70 mg/dL) from exercise commencement to 2 h post-exercise, with each TT condition compared with TT60 via sign rank test.

resultsThe primary outcome, median TBR, was 0% from exercise commencement to 120 min post-exercise for all conditions with no difference between TT conditions. Insulin delivery in the 2 h pre-exercise was higher for TTnil compared to TT60 (1.3 [0.9, 2.4] Units vs. 2.0 [1.1, 3.0] Units; p = 0.013); however there was no difference between TT conditions for starting glucose, time in range (TIR) or for the number of participants who experienced a hypoglycaemia episode from exercise commencement to 2 h post-exercise.

conclusionsGlycaemia with exercise was excellent regardless of TT timing, which had no measurable effect on TBR during and post-exercise in a well-controlled cohort in the absence of a recent meal.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 1ExerciseGlycemic ControlHypoglycemiaHypoglycemic AgentsInsulinInsulin Infusion SystemsAdultBlood Glucose Self-MonitoringFemaleHumansMaleMiddle AgedTime FactorsYoung AdultBlood GlucoseHypoglycemic AgentsInsulinexercise interventionglycaemic controlhypoglycaemiatype 1 diabetes

Identifiers

PMID40566793
PMCPMC12326887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.