ArticleFood chemistry: X2025
Activation of the calcium-sensing receptor by glutathione maillard products: Implications for kokumi sensation.
Article in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Kokumi Peptides in Salt Reduction: Preparation, Evaluation Methods, Perceptual Mechanisms, and Prospects for Food Applications.Journal of food science · 2026Review
- Kokumi substances as taste modulators: sensory properties and molecular mechanisms.Chemical senses · 2026Review
- Immune mechanisms in chronic kidney disease-mineral and bone disorder: current insights and therapeutic implications.Frontiers in medicine · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kokumi peptides, such as glutathione (GSH), activate the calcium-sensing receptor (CaSR) in taste buds, evoking distinct sensory attributes. Foods containing GSH-derived Maillard reaction products (MRPs) often exhibit kokumi characteristics, but their direct interaction with CaSR remains unclear. In this study, GSH was thermally reacted with reducing sugars (glucose, xylose) at 80 °C, 120 °C, and 150 °C. The resulting MRPs were evaluated for browning, volatile profiles (GC-MS), and CaSR activation using a fluorescence-based cell assay. GSH-xylose MRPs showed greater browning and distinct volatile profiles compared to GSH-glucose MRPs. Notably, GSH-glucose MRPs showed highest CaSR activity at >120 °C, followed by GSH-xylose MRPs, likely acting as positive allosteric modulators. This provides the first evidence of allosteric modulation of CaSR by GSH-sugar MRPs, offering mechanistic insight into receptor interaction. However, the lack of sensory validation remains a limitation, and further studies are needed to confirm the perceptual relevance of these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.