Functional connectivity of subsystems of the default-mode network in patients with early psychotic symptoms.

Nicky Lute, Imke Lemmers-Jansen, Lydia Krabbendam, Mariët van Buuren

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Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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1 citing paper in PubMed.

Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis.Schizophrenia (Heidelberg, Germany) · 2026
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5 · Who and what money

Authors and funding

4 authors.

Nicky LuteDepartment of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences. Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT Amsterdam, the Netherlands.

Imke Lemmers-JansenDepartment of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences. Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT Amsterdam, the Netherlands.

Lydia KrabbendamDepartment of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences. Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT Amsterdam, the Netherlands.

Mariët van BuurenDepartment of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences. Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resting-state connectivity of the default-mode network (DMN) is aberrant in patients with chronic psychotic disorders as well in individuals with early stage psychosis. Studies of the DMN in healthy volunteers revealed that the DMN comprises several subnetworks. However, it is not yet clear if connectivity between and within these DMN subnetworks is aberrant in patients with early psychotic symptoms nor whether these connectivity patterns are related to symptomatology. This initial investigation examined functional connectivity between and within the DMN subnetworks in patients with early psychotic symptoms and in healthy volunteers, and probed how these connectivity patterns were related to the severity of clinical symptomatology. Functional connectivity was measured during resting-state in 30 patients with early psychotic symptoms and in 39 controls using functional MRI. We did not observe differences in connectivity within and between the subnetworks of the DMN between the control group and the early psychosis group. However, lower functional connectivity between the medial prefrontal and posterior medial subnetworks and between medial prefrontal and anterior temporal subnetworks of the DMN did predict the severity of the negative symptoms. The findings of this initial investigation provide insight into the associations between functional connectivity of DMN subnetworks and symptomatology in patients with early psychotic symptoms.

Indexed as

Default mode networkFunctional connectivityPsychosisPsychotic symptomsResting-state

Identifiers

PMID40567890

DOI10.1016/j.ynirp.2025.100248

PMCPMC12172822

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