ArticleAlzheimer's & dementia (New York, N. Y.)
The impact of estimated cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Divergent associations of estimated cardiorespiratory fitness with cognitive trajectories in Chinese and U.S. middle-aged and older adults: A descriptive cross-national comparison from CHARLS and HRS.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Lifestyle strategies and mechanistic implications for slowing neurodegeneration.npj metabolic health and disease · 2026Review
- The impact of estimated cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline.Alzheimer's & dementia (New York, N. Y.)Article
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18 authors.
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Abstract
introductionThe accumulation of core Alzheimer's disease (AD) pathology contributes to cognitive decline. Cardiorespiratory fitness (CRF) influences AD pathological progression resulting in improvement or maintenance of cognitive function with age. CRF-related differences in accumulation rates or risk of reaching clinically relevant AD biomarker levels, and potentially interactive effects of core AD pathology and CRF on cognitive decline, remain largely unknown.
methodsParticipants (
resultsThere were no significant relationships between eCRF and biomarker trajectories. However, those in high eCRF group who were Aβ- at baseline had a significantly lower risk of becoming biomarker-positive (Aβ-PET: HR, 95% confidence interval [CI] = 0.42, 0.20-0.88; p-tau-217: 0.45, 0.21-0.97) compared to the low eCRF group. The detrimental relationship between Aβ accumulation and cognitive decline was significantly attenuated for Aβ+/T+ with high eCRF. DISCUSSION: Although eCRF did not influence core AD biomarker accumulation trajectories, high eCRF seems protective against becoming biomarker-positive and attenuates the known deleterious relationship between biomarker accumulation and cognitive decline in Aβ+/T+. Highlights: High estimated cardiorespiratory fitness (eCRF) is associated with a lesser likelihood of becoming AD biomarker positive.High eCRF did not alter biomarker accumulation in those positive for Alzheimer's disease (AD) pathology.High eCRF attenuated the relationship between AD biomarkers and cognitive decline.Innovative methods: Stratifying analyses by amyloid beta and tau status.
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