Evidence map›Paper›PMID 40568108›Full record

ArticlebioRxiv : the preprint server for biology2025

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma.

Shuhei Asada, Guangli Zhu, Jithma Prasad Abeykoon, Yutaro Tanaka, Huy Nguyen, Yuna Hirohashi, Divya R Iyer, Nicholas William Ashton, Sirisha Mukkavalli, Martha Velazquez and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Shuhei AsadaDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6116-7996
Guangli ZhuDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Jithma Prasad AbeykoonDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Yutaro TanakaDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0009-0004-1060-7065
Huy NguyenDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Yuna HirohashiDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Divya R IyerDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Nicholas William AshtonDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Sirisha MukkavalliDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8875-7985
Martha VelazquezDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Lige JiangDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Miles Del BussoDivision of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
Judith Jebastin ThangaiahDepartment of Pathology, Mayo Clinic, MN, USA.
Steven I RobinsonDepartment of Oncology, Mayo Clinic, MN, USA.
Kalindi ParmarDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Eliezer M Van AllenCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0201-4444
Riaz GillaniDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Geoffrey I ShapiroDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3331-4095
Alan D D'AndreaDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6168-6294

Funding

Tissue and Pathology CoreP50CA168504 · NCI · DANA-FARBER CANCER INST · PI LEIF W ELLISEN, NANCY U LIN · 2013 to 2026
$30.1M
Project 2: Combined personal neoantigen-targeting cancer vaccines with immune checkpoint blockade for ovarian cancerP50CA240243 · NCI · DANA-FARBER CANCER INST · PI CASTRO, CESAR M · 2020 to 2024
$11.5M
MOLECULAR PATHOGENESIS OF FANCONI ANEMIAR01HL052725 · NHLBI · DANA-FARBER CANCER INSTITUTE · PI ALAN D. D'ANDREA · 1994 to 2026
$5.9M
Exploiting a Novel DNA Repair Defect in Ewing SarcomaR01CA296618 · NCI · DANA-FARBER CANCER INST · PI ALAN D. D'ANDREA · 2025 to 2026
$1.0M
NCI NIH HHS P50 CA168504NCI NIH HHS P50 CA240243NCI NIH HHS R01 CA296618NHLBI NIH HHS R01 HL052725
6 · The paper itself

Abstract

Ewing sarcoma (EwS) is a group of bone and soft tissue cancers in children and young adults. Since EwS cells have pronounced sensitivity to radiation and chemotherapy-induced DNA damage, the role of the oncoprotein, EWS-FLI1, in DNA repair is likely. Here, we demonstrate that EWS-FLI1 causes a defect in microhomology-mediated end-joining (MMEJ) repair. EWSR1 is a splicing factor that promotes the faithful splicing of the

Indexed as

Alternative end-joiningCDK12DNA double-strand breaksDNA-PKcEwing’s Sarcomathe Fanconi Anemia pathwayTMEJ

Identifiers

PMID40568108
PMCPMC12191234

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.