ArticlebioRxiv : the preprint server for biology2025
EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injury.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Aims: The epidermal growth factor (EGF) receptor family of tyrosine kinases regulates development and homeostasis of digestive organs including the liver and bile ducts. It consists of four receptors, EGF receptor (EGFR) and erythroblastoma oncogene B 2-4 (ERBB2-4), and their corresponding ligands. EGF signaling promotes intrahepatic cholangiocyte proliferation, bipotent cell transdifferentiation into cholangiocytes, bile duct branching, and cholangiocarcinoma (CCA) aggressiveness.The EGF family signaling contribution to extrahepatic bile duct (EHBD) regeneration is not well defined. This work is aimed at determining the fundamental role of the EGF signaling network in the biliary proliferative response to EHBD obstruction. Approach: We used mouse bile duct ligation to model obstructive EHBD injury, and human and mouse EHBD organoids for Results: At homeostasis, the EHBD expressed EGFR ligands Conclusion: The obstruction-induced biliary proliferation is an EGFR-mediated response suggesting context-and receptor-specific EGF signaling network involvement in EHBD regeneration after injury.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.