ArticleWorld journal of nephrology2025
Investigating the controversial link between pediatric obesity and graft survival in kidney transplantation.
Article in World journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Kidney transplant outcomes in obese pediatric patients.World journal of nephrology · 2025Article
- Obesity and pediatric renal transplant: An unholy alliance.World journal of nephrology · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundChildhood obesity is a significant public health concern, particularly amongst children with chronic kidney disease requiring kidney transplant (KT). Obesity, defined as a body mass index (BMI) of 30 kg/m² or greater, is prevalent in this population and is associated with disease progression. While BMI influences adult KT eligibility, its impact on pediatric transplant outcomes remains unclear. This study investigates the effect of BMI on graft survival and patient outcomes, addressing gaps in the literature and examining disparities across BMI classifications.
aimTo assess the impact of BMI classifications on graft and patient survival following KT.
methodsA retrospective cohort study analyzed 23081 pediatric transplant recipients from the Standard Transplant Analysis and Research database (1987-2022). Patients were grouped into six BMI categories: Underweight, healthy weight, overweight, and Class 1, 2, and 3 obesity. Data were analyzed using one-way way analysis of variance, Kruskal-Wallis tests, Chi-squared tests, Kaplan-Meier survival analysis with log-rank tests, and Cox proportional hazard regressions. Statistical significance was set at
resultsClass 3 obese recipients had lower 1-year graft survival (88.7%) compared to healthy-weight recipients (93.1%,
conclusionSevere obesity and underweight status are associated with poorer long-term outcomes in pediatric KT recipients, emphasizing the need for nuanced transplant eligibility criteria addressing obesity-related risks and socioeconomic disparities.
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