ReviewFrontiers in endocrinology2025
Metabolic syndrome in children and adolescents: definitions, epidemiology, pathophysiology, interventions, and challenges.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Assessing the Diagnostic Performance of Triglyceride-Glucose-Based Indices for Early Detection of Metabolic Syndrome in Paediatric Down Syndrome.Journal of intellectual disability research : JIDR · 2026Article
- Exercise as a Molecular Therapeutic Strategy in Metabolic Syndrome: Integrating Cellular Signaling, Organ Crosstalk, and Clinical Translation-A Narrative Review.Current issues in molecular biology · 2026Review
- Article
- Discriminative Ability of TyG, TyG-WC, BAI, FGIR, and QUICKI Indexes in Identifying Metabolic Syndrome in a Pediatric Population with Obesity.Metabolites · 2026Article
- Multi-Targeted Intervention ofMetabolites · 2026Review
- Cardiovascular disease burden in children with obesity: A narrative review.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- The Effect of Ultra-Processed Food Consumption and Physical Activity on Fatty Acid Profiles in Young Muslims in Melilla.Healthcare (Basel, Switzerland) · 2026Article
- Environmental Radon Exposure and Inflammatory Responses in Children and Adolescents: Evidence from a High-Radon Region in Kazakhstan.Biomedicines · 2026Article
- Physical Activity Patterns and Cardiometabolic Risk in Children and Adolescents with Obesity: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications.Biomedicines · 2026Review
- The Impact of Modern Lifestyles on Spinal Health in the Pediatric Population: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Functional Foods as Modulators of Epigenetic Mechanisms Affecting Metabolic Health in Adolescence.International journal of molecular sciences · 2026Review
- Obesity, Metabolic Syndrome and MASLD in Children: Inflammation as the Missing Link-A Short Narrative Review.Life (Basel, Switzerland) · 2026Review
- Skin Carotenoid Score as a Potential Early Biomarker of Metabolic Syndrome Risk in Adolescents.Nutrients · 2026Article
- Syndrome differentiation and treatment of pediatric central precocious puberty: role of the spleen-kidney axis.Frontiers in immunology · 2026Review
- Cross-sectional analysis of the association between physical activity and metabolic syndrome in the elderly.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome (MetS) is a group of cardiometabolic risk factors with high prevalence in the adult population. To date, there is no consensus on the definition for MetS in children and adolescents despite the presence of well-established diagnostic criteria in adults. The etiology of MetS is associated with a complex interaction between genetic susceptibility and environmental factors, in which the modifiable environmental risk factors are considered to play an important role in this process. MetS is significantly associated with an increased risk of diabetes mellitus and cardiovascular diseases (CVDs). Thus, it is necessary to pay attention to the prevention of MetS in childhood and adulthood. Given the current epidemic of obesity in children and adolescents, there is an urgent need to provide adequate guidelines for the definition, screening, and treatment strategies of MetS in younger patients. In this narrative review, we provide some diagnostic criteria and epidemiological studies and highlight the pathogenesis and management of MetS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.