ArticlemedRxiv : the preprint server for health sciences2025
The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders.
Abstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chromosome 15q Structural Variants Associated with Syndromic Autism Spectrum Disorder: Clinical and Genomic Insights from Three Case Reports in a Brazilian Reference Center.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors.
Andrew D GrotzingerDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO.ORCID 0000-0001-7852-9244
Josefin WermeDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5015-2078
Wouter J PeyrotDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-7954-8383
Oleksandr FreiCenter for Bioinformatics, Department of Informatics, University of Oslo, Blindern, Oslo, Norway.ORCID 0000-0002-6427-2625
Christiaan de LeeuwDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-1128-5390
Lucy K BicksDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0002-9884-0133
Qiuyu GuoDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0001-8549-8335
Michael P MargolisDepartment of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-3706-8960
Brandon J CoombesDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4322-5923
Anthony BatzlerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3753-4930
Vanessa PazdernikDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7566-7334
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9350-4440
Ole A AndreassenKG Jebsen Centre for Neurodevelopment, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Verneri AnttilaAnalytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Anders D BørglumCenter for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark.ORCID 0000-0001-8627-7219
Na CaiComputational Health Centre, Helmholtz Munich, Neuherberg, Germany.ORCID 0000-0001-7496-2075
Ditte DemontisCenter for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark.ORCID 0000-0001-9124-2766
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN USA.ORCID 0000-0003-0344-9690
Stephen V FaraoneDepartment of Neuroscience and Physiology, Norton College of Medicine, SUNY Upstate Medical Universitiy, Syracuse, NY.ORCID 0000-0002-9217-3982
Barbara FrankeDept Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-4375-6572
Michael J GandalDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5800-5128
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4067-1859
John M HettemaDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, College Station, Texas, USA.ORCID 0000-0002-0105-9034
Katherine G JonasDepartment of Psychiatry & Behavioral Health, Stony Brook University.ORCID 0000-0002-1910-223X
James A KnowlesDepartment of Genetics, Rutgers University, Piscataway, NJ.ORCID 0000-0002-3307-5741
Karestan C KoenenBroad Institute of MIT and Harvard, Boston, MA, USA.ORCID 0000-0003-2978-7655
Adam X MaihoferCenter of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, US.ORCID 0000-0003-4517-1623
Travis T MallardCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3265-3001
Manuel MattheisenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-8442-493X
Karen S MitchellDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA US.ORCID 0000-0002-1516-7239
Benjamin M NealeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1513-6077
Caroline M NievergeltCenter of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, US.ORCID 0000-0001-5766-8923
John I NurnbergerDepartment of Medical and Molecular Genetics, Department of Psychiatry, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis IN USA.ORCID 0000-0002-7674-1767
Kevin S O'ConnellNORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-6865-8795
Elise B RobinsonStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2314-2792
Sandra S Sanchez-RoigeDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA USA.ORCID 0000-0001-6137-5699
Susan L SantangeloCenter for Clinical and Translational Science, Maine Health Institute for Research, Portland, ME, USA.ORCID 0000-0001-5576-4495
Hreinn StefanssondeCODE genetics / Amgen, Reykjavik, Iceland.ORCID 0000-0002-9331-6666
Kari StefanssondeCODE genetics / Amgen, Reykjavik, Iceland.ORCID 0000-0003-1676-864X
Murray B SteinDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA USA.ORCID 0000-0001-9564-2871
Nora I StromCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm, Health Care Services, Region Stockholm, Sweden.ORCID 0000-0002-5261-8852
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill.ORCID 0000-0001-9384-7988
Elliot M Tucker-DrobCenter on Aging and Population Sciences, University of Texas at Austin.ORCID 0000-0001-5599-6237
Brad VerhulstDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, College Station, Texas, USA.ORCID 0000-0001-5369-9757
Irwin D WaldmanDepartment of Psychology, Emory University.ORCID 0000-0002-6862-1837
G Bragi WaltersdeCODE genetics / Amgen, Reykjavik, Iceland.ORCID 0000-0002-5415-6487
Naomi R WrayDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0001-7421-3357
Anxiety Disorders Working Group
Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group
Autism Spectrum Disorders Working Group
Bipolar Disorder Working Group
Eating Disorders Working Group
Major Depressive Disorder Working Group
Nicotine Dependence GenOmics (iNDiGO) Consortium
Obsessive-Compulsive Disorder Working Group
Post-Traumatic Stress Disorder Working Group
Schizophrenia Working Group
Substance Use Disorders Working Group
Tourette Syndrome Working Group
Phil H LeePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1770-3100
Kenneth S KendlerDepartment of Psychiatry, Virginia Commonwealth University, Richmond VA, USA.ORCID 0000-0001-8689-6570
Jordan W SmollerBroad Institute of MIT and Harvard, Boston, MA, USA.ORCID 0000-0002-0381-6334
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MUnderstanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Frances E. Carr · 2017 to 2026
$51.6MAfrican Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7MPsychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4MSLE Treatment with N-acetylcysteineU01AR076092 · NIAMS · UPSTATE MEDICAL UNIVERSITY · PI Michael P McDermott, Andras Perl · 2020 to 2026
$7.9M4/4-Psychiatric GWAS Consortium:Genomic Follow-Up Next-Gen Sequencing & GenotypiU01MH096296 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SKLAR, PAMELA · 2012 to 2015
$7.3MLatino Ancestry Genomic Psychiatry CohortR01MH123451 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2020 to 2025
$7.1MPerson-centered diagnostics and prediction for child dysregulatory psychopathology using novel phenotypesU01MH135970 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI KARALUNAS, SARAH LYN, NAGEL, BONNIE J. · 2024 to 2025
$6.5M2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4MProgram Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2MScientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1MNIAMS NIH HHS U01 AR076092NIA NIH HHS P30 AG066614NIA NIH HHS R01 AG073593NICHD NIH HHS P2C HD042849NIDA NIH HHS DP1 DA054394NIDA NIH HHS R01 DA054869NIGMS NIH HHS R01 GM148494NIGMS NIH HHS U54 GM115516NIMH NIH HHS F30 MH135712NIMH NIH HHS K08 MH122673NIMH NIH HHS K08 MH135343NIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH112904NIMH NIH HHS R01 MH116037NIMH NIH HHS R01 MH119243NIMH NIH HHS R01 MH120219NIMH NIH HHS R01 MH121521NIMH NIH HHS R01 MH121924NIMH NIH HHS R01 MH123451NIMH NIH HHS R01 MH123775NIMH NIH HHS R01 MH123922NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH124847NIMH NIH HHS R01 MH124851NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH124873NIMH NIH HHS R01 MH124875NIMH NIH HHS R01 MH130899NIMH NIH HHS R01 MH131685NIMH NIH HHS R01 MH136149NIMH NIH HHS R21 MH123908NIMH NIH HHS U01 MH085508NIMH NIH HHS U01 MH085513NIMH NIH HHS U01 MH085518NIMH NIH HHS U01 MH085520NIMH NIH HHS U01 MH094411NIMH NIH HHS U01 MH094421NIMH NIH HHS U01 MH094432NIMH NIH HHS U01 MH096296NIMH NIH HHS U01 MH109499NIMH NIH HHS U01 MH109501NIMH NIH HHS U01 MH109514NIMH NIH HHS U01 MH109528NIMH NIH HHS U01 MH109532NIMH NIH HHS U01 MH109536NIMH NIH HHS U01 MH109539NIMH NIH HHS U01 MH135970NIMH NIH HHS U24 MH068457NINDS NIH HHS R01 NS128535
Abstract
Psychiatric disorders display high levels of comorbidity and genetic overlap
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.