Evidence map›Paper›PMID 40568929›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models.

Run-Zhou Yang, Fang Li, Jiao Liu, Shu-Ang Li, Dan-Hua Liu, Zhuanbin Wu, Pei-Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Run-Zhou YangClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Fang LiDepartment of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200000, China.
Jiao LiuDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Shu-Ang LiClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Dan-Hua LiuClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhuanbin WuReplatium Inc., 55 YuanZhong Road, PuDong New Area, Shanghai, 201300, China.
Pei-Pei LiuClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Wenju LiuSchool of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Bin ZhouShanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Cizhong JiangSchool of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Haibing ZhangShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
Ying YuDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Jian-Sheng KangClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.ORCID https://orcid.org/0000-0002-2603-9718

Funding

Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University ZYCXTD2023014Joint Construction Program for Medical Science and Technology Development of Henan Province of China 2018020088Joint Construction Program for Medical Science and Technology Development of Henan Province of China: LHGJ20190239National Natural Science Foundation of China 32000522National Natural Science Foundation of China 32000855National Natural Science Foundation of China 32071137National Natural Science Foundation of China 92054103Natural Science Foundation of Henan Province of China 202300410420
6 · The paper itself

Abstract

SYNTAXIN 12/13 (STX12), a member of the syntaxin protein family enriched in the brain and heart, plays important roles in vesicle recycling. Currently, the role of STX12 in cardiovascular physiology remains unclear. Using zebrafish and mice, it is shown that STX12 loss leads to pericardial edema, cardiac malformations, and heart failure. Stx12 depletion disrupts mitochondrial morphology, reduces iron and zinc levels, and impairs ATP production. Stx12-deficient cardiomyocytes exhibit prolonged repolarization due to decreased sarcoplasmic reticulum Ca

Indexed as

Heart FailureMitochondriaSarcoplasmic Reticulum Calcium-Transporting ATPasesSirolimusAnimalsDisease Models, AnimalMiceMyocytes, CardiacZebrafishSarcoplasmic Reticulum Calcium-Transporting ATPasesSirolimusheart failuremitochondriarapamycinSERCASyntaxin 12/13

Identifiers

PMID40568929
PMCPMC12376582

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.