Evidence map›Paper›PMID 40568955›Full record

ArticleYeast (Chichester, England)2025

Cooperative Function of Atg8- and TORC1-Mediated Activities in Yeast.

Yumiko Oba, Miyuki Higuchi, Naoka Takahashi, Haruko Katsuta, Naoki Koike, Takashi Ushimaru, Yoko Kimura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Yeast (Chichester, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yumiko ObaDepartment of Agriculture, Shizuoka University, Shizuoka, Japan.ORCID 0009-0007-3300-9756
Miyuki HiguchiDepartment of Agriculture, Shizuoka University, Shizuoka, Japan.
Naoka TakahashiGraduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.
Haruko KatsutaGraduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.
Naoki KoikeGraduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.
Takashi UshimaruGraduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.ORCID 0000-0003-4589-7408
Yoko KimuraDepartment of Agriculture, Shizuoka University, Shizuoka, Japan.ORCID 0000-0003-0775-0368

Funding

This study was supported by the Collaborative Project of the Departments of Science and Agriculture at Shizuoka University (to Yoko Kimura and Takashi Ushimaru), the Takeda Foundation (to Yoko Kimura), the Japan Society for the Promotion of Science (JSPS) (Grants-in-Aid for Scientific Research; grant No. 20K06620 and 23K05145 to Yoko Kimura, and 18K06212, 20H05317, and 21H02475 to Takashi Ushimaru), and the Institute for Fermentation, Osaka (grant No. G-2020-2-055 to Takashi Ushimaru).
6 · The paper itself

Abstract

The target of rapamycin complex 1 (TORC1) protein kinase plays an important role in regulating various cellular activities in response to nutrient availability. In this study, an autophagy-related protein 8 (atg8) mutant of Saccharomyces cerevisiae was highly sensitive to cellular processes in which TORC1 activity was inhibited by rapamycin treatment or by a mutated allele of KOG1 which encodes a subunit of TORC1. Atg8 exhibits both lipidation-dependent and -independent activities, each involving distinct factors. Lipidation of Atg8 is necessary for autophagy and functions with autophagy-related proteins like Atg7, whereas the lipidation-independent activities of Atg8 require Hfl1. The atg7Δhfl1Δ double mutant exhibited defects for the impaired TORC1 activities, suggesting that both lipidation-dependent and -independent functions of Atg8 are required for survival during impaired TORC1 activity. Moreover, atg8Δ and atg7Δhfl1Δ mutants exhibited sensitivity to metal ion Zn

Indexed as

Autophagy-Related Protein 8 FamilySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsAutophagyMutationSirolimusZincATG8 protein, S cerevisiaeAutophagy-Related Protein 8 FamilySaccharomyces cerevisiae ProteinsSirolimusTORC1 protein complex, S cerevisiaeTranscription FactorsZincAtg8Hfl1rapamycinTORC1vacuoleyeast

Identifiers

PMID40568955
PMCPMC12511908

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.