ArticleShock (Augusta, Ga.)2026
Trauma and Hemorrhage Lead to An Elevation in Fecal Hort-Chain Fatty Acids.
Article in Shock (Augusta, Ga.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionSevere trauma and hemorrhage in rats lead to changes in the beta diversity of the commensal bacteria found in the gut. Because short-chain fatty acids (SCFA) are produced by these bacteria, SCFA concentration may also change following trauma and hemorrhage and reflect these alterations in the microbiome.
objectiveTo determine whether changes in SCFA occur after trauma and hemorrhage in the feces and plasma of rodents. MATERIALS AND
methodsPolytrauma was induced in isoflurane-anesthetized Sprague-Dawley rats by damage to the small intestine, liver, right leg skeletal muscle, and femur, followed by 20% hemorrhage. Whole blood resuscitation was performed at 1 h (20%). Rats were euthanized at 2 h and feces and plasma were analyzed for short-chain fatty acids (SCFA) by liquid chromatography tandem mass spectroscopy.
resultsOf 21 SCFA analyzed in the feces and plasma, 11 were measurable. In feces, five demonstrated a significant elevation after 2 h of severe trauma and hemorrhage (n-8) including propionic (37,775 ± 8,919 vs. 146,591 ± 46,734 nM/mg protein: mean ± SEM), pentanoic (10,975 ± 2,981 vs. 41,828 ± 10,645), 2-methyl propionic (2,621 ± 523 vs. 13,798 vs. 2083), 4-methyl pentanoic (1,134 ± 302 vs. 4,320 ± 1,029), and 3-phenyl propionic acid (42,194 ± 4,863 vs. 153,024 ± 38,473). The addition of whole blood resuscitation did not change these responses, but led to an additional significant elevation in butyric (68,551 ± 10,786 vs. 369,951 ± 79,515) and hexanoic acid (24,548 ± 6,791 vs. 102,002 ± 32,069). There was no change in SCFA after trauma, hemorrhage or resuscitation in the plasma (n = 6).
conclusionTwo hours of severe trauma and hemorrhage lead an elevation in many SCFAs in rat feces. No change in SCFA was found in plasma. Because SCFA are primarily derived from commensal bacteria in the gut, these data suggest that the measurement of SCFA could be used as an index of changes in the gut microbiome in pathological condition including trauma and hemorrhage.
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