Evidence map›Paper›PMID 40569359›Full record

ArticleMolecular biology reports2025

Cytokine profiles and metabolic dysregulation in endometriosis: insights into diagnostic and therapeutic targets.

Ashish Ashish, Sangeeta Rai, Shivani Mishra, Anil Kumar Maurya, Abhay Kumar Yadav, Shani Vishwakarma, Royana Singh

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashish AshishMultidisciplinary Research Unit, Institute of Medical Sciences, ICMR-DHR, Banaras Hindu University, Varanasi, 221005, India.
Sangeeta RaiDepartment of Obstetrics & Gynaecology, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India.
Shivani MishraDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India.
Anil Kumar MauryaDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India.
Abhay Kumar YadavDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India.
Shani VishwakarmaDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India.
Royana SinghDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India. royanasingh@bhu.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEndometriosis is a chronic inflammatory disorder marked by the ectopic growth of endometrial-like tissue, affecting 10–15% of women of reproductive age. Pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) drive inflammation and disease progression, while anti-inflammatory cytokines (TGF-β, IL-10) maintain immune balance. Metabolic markers like homocysteine, folic acid, and vitamin B12 may influence immune regulation and contribute to endometriosis pathophysiology. METHODOLOGY: Serum levels of TNF-α, IL-1β, IL-6, IL-10, TGF-β, CRP, Ferritin, IL-4, IFN-γ, Homocysteine, Folic Acid, and Vitamin B12 were quantified using ELISA kits. Unpaired t-tests and Pearson correlation were used to assess immune-metabolic differences between endometriosis patients and healthy controls.

resultsTNFα, IL-6, IL-1β, IL-10, homocysteine, ferritin, and reduced IFN-γ and CRP levels in the case group compared to controls (p < 0.05). TNFα (p = 0.0008), IL-1β (p = 0.0005), and homocysteine (p < 0.0001) were notably higher in cases. IFN-γ (p < 0.0001) and CRP (p < 0.0001) were significantly lower in cases. IL-6 (p = 0.0020), IL-10 (p = 0.0051), ferritin (p = 0.0338), and folate (p = 0.0134) also showed significant differences. TGF-β, IL-4, and Vit-B12 levels did not differ significantly (p > 0.05). These findings suggest altered cytokine and biochemical profiles in disease pathophysiology.

conclusionThe study highlights significant alterations in inflammatory cytokines and metabolic markers in endometriosis patients compared to healthy controls. Elevated pro-inflammatory and altered anti-inflammatory cytokine levels, along with metabolic imbalance, suggest immune-metabolic dysregulation in disease pathogenesis. These findings may aid in identifying potential biomarkers and therapeutic targets for endometriosis.

Indexed as

CytokinesEndometriosisAdultBiomarkersCase-Control StudiesC-Reactive ProteinFemaleFerritinsFolic AcidHomocysteineHumansInflammationInterferon-gammaInterleukin-10Interleukin-1betaInterleukin-6BiomarkersC-Reactive ProteinCytokinesFerritinsFolic AcidHomocysteineInterferon-gammaInterleukin-10Interleukin-1betaInterleukin-6Transforming Growth Factor betaTumor Necrosis Factor-alphaVitamin B 12CRPEndometriosisFerritinFolic acidHomocysteineIL-1βIL-6Immune dysregulationInflammatory cytokinesOxidative stressVitamin B12

Identifiers

PMID40569359

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.