ReviewNaunyn-Schmiedeberg's archives of pharmacology2025
Morin: a promising hepatoprotective agent against drug and chemical-induced liver injury.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Crosstalk along the gut-liver axis modulates glutathione and cadmium-induced hepatotoxicity.Frontiers in immunology · 2026Review
- Ameliorated Hepatoprotective Aptitude of Novel Lignin Nanoparticles on APAP-Induced Hepatotoxicity in a Murine Model.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Investigation of the inhibitory effects of total flavonoids of litchi seed onFrontiers in cellular and infection microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morin, a naturally occurring flavonoid found in various fruits and medicinal plants, has long been recognized in ethnopharmacological practices for its therapeutic potential. While its antioxidant and anti-inflammatory properties have been appreciated historically, recent molecular studies have begun to uncover the precise mechanisms underlying its protective actions, particularly in the context of liver toxicity induced by drugs and chemicals. Morin has demonstrated significant hepatoprotective effects through its ability to attenuate oxidative stress, suppress pro-inflammatory cytokines, and regulate apoptotic pathways in hepatocytes. Multiple cellular targets and signaling pathways, including Nrf2/HO-1, NF-κB, MAPK, SphK1/S1P, and ADMA/DDAH, have been shown to be modulated by morin, indicating its multi-faceted protective profile. This review explores the molecular mechanisms of morin to enhance understanding of its therapeutic potential and support its future clinical application against drug- and chemical-induced liver injury.
Indexed as
Identifiers
40569367What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.