ArticlePoultry science2025
Immune stress impairs broiler performance by affecting hypothalamic methylation modification and intestinal 5-HT synthesis.
Article in Poultry science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Advances in RNA m6A modification research and its role in poultry economic traits.Poultry science · 2026Review
- NPoultry science · 2026Review
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
- Alleviating the Adverse Effects of Lipopolysaccharide on Production Performance, Immune Function, and Intestinal Damage in Broilers via Dietary Alkaline Phosphatase.Animals : an open access journal from MDPI · 2026Article
- Lactobacillus-vectored nanobodies improve broiler productivity under sub-clinical necrotic enteritis with associated microbiome and transcriptome changes.NPJ biofilms and microbiomes · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this experiment, a chronic immune stress model was established in broiler chickens by injecting lipopolysaccharide (LPS). The objective was to investigate the impact of immune stress on performance and intestinal mucosal barrier function in broiler chickens and identify key molecular and neuroendocrine pathways contributing to these effects. We randomly divided 160 one-day-old male white-feathered broilers into two groups: the control group (CON) and the LPS immune stress group (LPS), with 8 replicates of 10 chickens each. The LPS group received 0.5 mg/kg body weight LPS injections at 14 days of age for 10 consecutive days, while the control group received saline injections. The results indicated that LPS injection significantly decreased broiler performance (P < 0.05) and increased immune organ indices and serum corticosterone levels (P < 0.05). The mRNA levels of IL-1β in the spleen, as well as TNF-α, IL-1β, and FABP1 in the ileum, and hypothalamic MCH and PREPRO, showed significant upregulation (P < 0.05). Conversely, the mRNA levels of CHGA, JAM2, PCNA, BCL2, and mTOR were significantly decreased in the ileum, along with a notable decrease in hypothalamic NPY (P < 0.05). There was also a tendency toward lower expression of mTOR protein in the ileum (P = 0.054). Moreover, serum 5-hydroxytryptamine (5-HT) levels and gene expression of 5-HT receptors in the ileum were significantly reduced (P < 0.05). Additionally, there was a significant increase in m
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