Evidence map›Paper›PMID 40570960›Full record

ArticleThe Journal of biological chemistry2025

The poly(A) polymerase Star-PAP is regulated by stably associated phosphoinositide messengers.

Tianmu Wen, Mo Chen, Vincent L Cryns, Richard A Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tianmu WenUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Mo ChenUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Vincent L CrynsUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA. Electronic address: vlcryns@medicine.wisc.edu.
Richard A AndersonUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA. Electronic address: raanders@wisc.edu.

Funding

Phosphoinositide Signaling in the Cytosol and NucleusR35GM134955 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson · 2020 to 2026
$5.0M
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor ProgressionR01CA286492 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson, VINCENT L. CRYNS · 2024 to 2026
$2.8M
NCI NIH HHS R01 CA286492NIGMS NIH HHS R35 GM134955
6 · The paper itself

Abstract

Star-PAP is a noncanonical poly(A) polymerase that controls gene expression. Star-PAP was previously reported to bind PIPKI⍺ and its product PI(4,5)P

Indexed as

PhosphatidylinositolsPolynucleotide AdenylyltransferaseHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHumansMolecular ChaperonesPhosphotransferases (Alcohol Group Acceptor)PTEN PhosphohydrolaseSignal TransductionTumor Suppressor Protein p531-phosphatidylinositol-4-phosphate 5-kinaseHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSPB1 protein, humaninositol polyphosphate multikinaseMolecular ChaperonesPhosphatidylinositolsPhosphotransferases (Alcohol Group Acceptor)Polynucleotide AdenylyltransferasePTEN PhosphohydrolasePTEN protein, humanTumor Suppressor Protein p53phosphatidylinositol transfer proteinsphosphoinositidephosphoinositide kinasesPIP(n)-linked proteinssmall heat shock proteinsStar-PAP

Identifiers

PMID40570960
PMCPMC12284501

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.