ArticleBMC microbiology2025
Analysis of gastric mucosa associated microbiota in functional dyspepsia using 16S rRNA gene next-generation sequencing.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Clinical Evidence Linking the Gut Microbiome and Functional Dyspepsia: A Systematic Review and Meta-Analysis.Biomedicines · 2026Review
- Characterization and Validation of the Antibacterial Activity ofFoods (Basel, Switzerland) · 2026Article
- The gut microbiota and plasma metabolites on functional dyspepsia: a study integrating Mendelian randomization and experimental validation.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric disorders have been associated with changes in the abundance and composition of microbiota, which typically coexist in symbiosis within the stomach. There is a scarcity of data regarding the presence of gastric mucosa-associated dysbiosis in functional dyspepsia. The present study aimed to characterize the taxonomy and diversities of the microbiota in the gastric mucosa of patients with functional dyspepsia. The study was conducted on a total of 50 paired antral and body gastric biopsies collected from the dyspepsia group (n = 15) and control group (n = 10). Microbial DNA was extracted from all gastric biopsies, followed by 16 S rRNA gene next-generation sequencing (NGS) using the Miseq Illumina platform. Firmicutes, Proteobacteria, and Bacteroides were the most predominant phyla in both groups, with a significant overrepresentation of Proteobacteria in the dyspepsia group (p value = 0.004). The genera Streptococcus, Prevotella, and Helicobacter were the most prevalent in both groups. The species of H. pylori and Prevotella melaninogenica were significantly more abundant in the dyspepsia group. The species of The LEfSe analysis revealed that E. coli, Helicobacter, Pseudomonas, Bifidobacteria, and Enterobacteriaceae were the most highly abundant and discriminating taxa in the gastric biopsies of the dyspepsia group compared to the control group. The microbial alpha diversity was significantly higher among gastric biopsies of dyspepsia than controls (P = 0.031). The beta diversity showed microbial dissimilarity between samples of dyspepsia and the control group. The 16 S rRNA gene NGS used in the present study demonstrated significant alteration in composition and diversities of gastric mucosa-associated microbiota among cases of functional dyspepsia compared to the controls. It is advisable to utilize advanced innovative technologies to gain a deeper understanding of the underlying pathophysiology of disrupted microbiota in gastric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.