Evidence map›Paper›PMID 40572504›Full record

ArticleMolecules (Basel, Switzerland)2025

Search for Antiviral Preparations in Series of New Derivatives of N-Substituted Piperidines.

Gulmira S Akhmetova, Ulzhalgas B Issayeva, Kaldybay D Praliyev, Ilya S Korotetskiy, Tulegen M Seilkhanov, Samir A Ross, Manas T Omyrzakov, Ubaidilla M Datkhayev, Khaidar S Tassibekov, Lyudmila N Ivanova and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gulmira S AkhmetovaLaboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences JSC, 106 Sh. Ualikhanov St., Almaty 050010, Kazakhstan.ORCID 0000-0002-9074-1464
Ulzhalgas B IssayevaLaboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences JSC, 106 Sh. Ualikhanov St., Almaty 050010, Kazakhstan.
Kaldybay D PraliyevLaboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences JSC, 106 Sh. Ualikhanov St., Almaty 050010, Kazakhstan.
Ilya S KorotetskiyScientific Center for Anti-Infectious Drugs JSC, Almaty 050060, Kazakhstan.ORCID 0000-0002-0397-7840
Tulegen M SeilkhanovThe Laboratory of Engineering Profile of NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, Kokshetau 020000, Kazakhstan.ORCID 0000-0003-0079-4755
Samir A RossNational Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.ORCID 0000-0002-3807-1299
Manas T OmyrzakovSchool of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan.ORCID 0000-0002-2665-178X
Ubaidilla M DatkhayevSchool of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan.
Khaidar S TassibekovLaboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences JSC, 106 Sh. Ualikhanov St., Almaty 050010, Kazakhstan.
Lyudmila N IvanovaScientific Center for Anti-Infectious Drugs JSC, Almaty 050060, Kazakhstan.ORCID 0000-0002-7194-0556
Natalya V ZubenkoScientific Center for Anti-Infectious Drugs JSC, Almaty 050060, Kazakhstan.

Funding

Research funding for this Project was provided by the Committee of Science of the Ministry of Science and High Education of the Republic of Kazakhstan. BR27101179
6 · The paper itself

Abstract

Cyanohydrin synthesis, as the simplest preparative method for introducing a carboxyl group into a piperidine molecule, has been used to obtain potentially biologically active piperidinecarboxylic acids, which have alkyl and arylalkyl radicals at the nitrogen atom of the piperidine ring. Hydrochlorides of cyclopropanecarboxylic acid esters based on piperidinecarboxylic acids, as well as hydrochlorides of fluorobenzoic acid esters of N-substituted piperidines, have been synthesized. The purpose of this study was to search for antiviral drugs among new piperidine derivatives. The structure of the synthesized compounds was studied by NMR methods, including COSY (

Indexed as

Antiviral AgentsPiperidinesAnimalsDogsHumansInfluenza A Virus, H1N1 SubtypeMadin Darby Canine Kidney CellsMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAntiviral AgentsPiperidinesantiviral activitycyanohydrinscytotoxicityesterspiperidine carboxylic acidspiperidines

Identifiers

PMID40572504
PMCPMC12196486

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.