Evidence map›Paper›PMID 40573134›Full record

ArticleNutrients2025

Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition.

Huixin Wu, Brittany L Witt, William J van der Pol, Casey D Morrow, Lennard W Duck, Trygve O Tollefsbol

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huixin WuDepartment of Biology, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-1979-9233
Brittany L WittDepartment of Biology, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
William J van der PolCenter for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Casey D MorrowDepartment of Cell, Departmental & Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Lennard W DuckDepartment of Med-Gastroenterology, Shelby Biomedical Research Building, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Trygve O TollefsbolDepartment of Biology, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-0284-1511

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Combinatorial epigenetic-based prevention of breast cancerR01CA178441 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TOLLEFSBOL, TRYGVE O · 2014 to 2025
$3.2M
NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA178441NIH HHS R01CA178441
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Breast NeoplasmsDietary FiberGastrointestinal MicrobiomeInulinIsothiocyanatesAnimalsAnticarcinogenic AgentsFemaleMiceMice, TransgenicPhosphatidylinositol 3-KinasesPhytochemicalsPrebioticsProto-Oncogene Proteins c-aktReceptors, EstrogenSignal TransductionAnticarcinogenic AgentsDietary FiberInulinIsothiocyanatesmTOR protein, mousePhosphatidylinositol 3-KinasesPhytochemicalsPrebioticsProto-Oncogene Proteins c-aktReceptors, EstrogensulforaphaneSulfoxidesTOR Serine-Threonine Kinasesbreast cancerepigenetic therapygut microbiomeinulintumor growth

Identifiers

PMID40573134
PMCPMC12196231

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.