Evidence map›Paper›PMID 40573339›Full record

ArticleViruses2025

Relationship Between Estimated Drug Distribution of Antiretroviral Therapy and Immune Proteins in Cerebrospinal Fluid During Chronic HIV Suppression.

Mattia Trunfio, Jennifer E Iudicello, Patricia K Riggs, Asha R Kallianpur, Todd Hulgan, Ronald J Ellis, Scott L Letendre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mattia TrunfioHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.
Jennifer E IudicelloHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.
Patricia K RiggsHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.
Asha R KallianpurDepartment of Genomic Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44106, USA.ORCID 0000-0002-6483-523X
Todd HulganDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ronald J EllisHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.ORCID 0000-0003-4931-752X
Scott L LetendreHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2001 to 2025
$15.2M
CHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespanR24MH129166 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 to 2025
$5.9M
Biopsychosocial Phenotypes and Potential Mechanisms in CHARTERR01MH125720 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 to 2025
$2.7M
NIMH NIH HHS P30 MH062512NIMH NIH HHS P30MH062512, R24MH129166, R01MH125720, R01MH095621NIMH NIH HHS R01 MH095621NIMH NIH HHS R01 MH125720NIMH NIH HHS R24 MH129166
6 · The paper itself

Abstract

Antiretroviral therapy (ART) drugs vary in their distribution into cerebrospinal fluid (CSF), which can be estimated using the central nervous system (CNS) penetration effectiveness (CPE) score. Although higher CPE has been associated with lower CSF HIV RNA levels, its relationship to CSF inflammation is less clear. We investigated associations between CPE and three CSF immune biomarkers (CXCL10, TNF-α, and IL-6) in 275 virally suppressed people with HIV (PWH) on three-drug ART regimens using a training-validation design. Participants were randomized into training (TG, n = 144) and validation (VG, n = 131) groups with similar demographics, ART characteristics, and CPE scores. The CSF levels of the biomarkers were quantified by bead suspension array-based immunoassays. In both groups, higher CPE correlated with lower levels of CXCL10 (TG: r = -0.31,

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsHIV InfectionsAdultBiomarkersCerebrospinal FluidChemokine CXCL10FemaleHumansInterleukin-6MaleMiddle AgedTumor Necrosis Factor-alphaViral LoadAnti-HIV AgentsAnti-Retroviral AgentsBiomarkersChemokine CXCL10CXCL10 protein, humanIL6 protein, humanInterleukin-6Tumor Necrosis Factor-alphaantiretroviralscentral nervous system penetration efficacychronic neuroinflammationCPECXCL10IL-6neuro HIVneurotargeted antiretroviral therapyTNF-α

Identifiers

PMID40573339
PMCPMC12197675

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.