Evidence map›Paper›PMID 40573391›Full record

ArticleViruses2025

Behavioral Dynamics, Genomic Insights, and Social Drivers of SARS-CoV-2 Waves and Variants in Cali, Colombia (2020-2023).

Diana López-Alvarez, Nelson Rivera-Franco, Erica Aristizabal, Melissa Solarte, Andrés Castillo, Carlos A Pardo, Beatriz Parra

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Metagenomic next-generation sequencing for comprehensive pathogen detection in intraocular infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. A comprehensive analysis of the SARS-CoV-2 omicron variant in Tocantins State, Brazil, and tracing the spread of the XBB.1.18.1 lineage.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diana López-AlvarezGrupo VIREM-Virus Emergentes y Enfermedad, Departamento de Microbiología, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia.ORCID 0000-0002-7734-8481
Nelson Rivera-FrancoGrupo VIREM-Virus Emergentes y Enfermedad, Departamento de Microbiología, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia.ORCID 0000-0002-4733-5452
Erica AristizabalGrupo VIREM-Virus Emergentes y Enfermedad, Departamento de Microbiología, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia.
Melissa SolarteGrupo VIREM-Virus Emergentes y Enfermedad, Departamento de Microbiología, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia.
Andrés CastilloLaboratorio de Técnicas y Análisis Ómicos-TAOLab/CiBioFi, Facultad de Ciencias Naturales y Exactas, Universidad del Valle, Calle 13 No 100-00, Cali 760015, Colombia.ORCID 0000-0001-9006-6721
Carlos A PardoDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-4128-5335
Beatriz ParraGrupo VIREM-Virus Emergentes y Enfermedad, Departamento de Microbiología, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia.ORCID 0000-0002-5371-7449

Funding

Emerging Neuroviruses and Neurological Inflammatory DiseasesR01NS110122 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PARDO-VILLAMIZAR, CARLOS A · 2019 to 2023
$1.7M
NIH HHS 1R01NS110122-01A1NINDS NIH HHS R01 NS110122
6 · The paper itself

Abstract

In Cali, Colombia, 405,689 COVID-19 cases were reported until March 2023, with 2463 complete genome sequences available for analysis. SARS-CoV-2 genomic data from Cali were analyzed to determine the prevalence of variants as well as the mutation frequencies. This study identified Nextstrain clades, Pango lineages, and specific mutations in key viral proteins. A total of 23 Nextstrain clades and 118 Pango lineages were detected, including variants of interest (Lambda, Mu) and variants of concern (Alpha, Gamma, Delta, Omicron). Analysis identified 2424 missense mutations, with notable frequencies in NSP3 (465), S (367), NSP2 (205), N (180), ORF3a (144), NSP12b (113), and NSP13 (108). The study also observed a high prevalence of simultaneous transmission of multiple variants. The COVID-19 epidemic waves in Cali were shaped more by social and economic dynamics than by the emergence of specific SARS-CoV-2 variants. These findings highlight the importance of context-specific public health interventions to mitigate future outbreaks effectively.

Indexed as

COVID-19SARS-CoV-2ColombiaGenome, ViralGenomicsHumansMutationPhylogenyepidemic wavesgenomic surveillancemutationssocial transmission

Identifiers

PMID40573391
PMCPMC12197799

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.