Evidence map›Paper›PMID 40574313›Full record

ArticleJournal of proteome research2025

Proteomic Analysis of FFPE Tissue Samples Identifies Potential Molecular Mechanisms Mediating Resistance to Radiotherapy in Rectal Cancer.

Tobias Zott, Michael Wolf, Günter Plessl-Walder, Heinz Regele, Michael Bergmann, Samuel M Meier-Menches, Christopher Gerner, Gerd R Silberhumer, Andrea Bileck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tobias ZottDepartment of General Surgery, Medical University of Vienna, Vienna 1090, Austria.
Michael WolfDepartment of Analytical Chemistry, University of Vienna, Vienna 1090, Austria.
Günter Plessl-WalderJoint Metabolome Facility, University of Vienna and Medical University of Vienna, Vienna 1090, Austria.
Heinz RegeleDepartment of Pathology, Medical University of Vienna, Vienna 1090, Austria.
Michael BergmannDepartment of General Surgery, Medical University of Vienna, Vienna 1090, Austria.
Samuel M Meier-MenchesDepartment of Analytical Chemistry, University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-8930-4574
Christopher GernerDepartment of Analytical Chemistry, University of Vienna, Vienna 1090, Austria.ORCID 0000-0003-4964-0642
Gerd R SilberhumerDepartment of General Surgery, Medical University of Vienna, Vienna 1090, Austria.
Andrea BileckDepartment of Analytical Chemistry, University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-7053-8856

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemoradiation prior to surgery in locally advanced rectal cancer is the current standard therapy but is not effective in all rectal cancer patients. Prognostic markers supporting patient stratification with respect to clinical response would therefore be desirable. The aim of this study was to investigate pathophysiological mechanisms underlying radioresistance and to identify potential prognostic markers by comparative proteome profiling. Therefore, formalin fixed paraffin-embedded tissue (FFPE) samples from rectal tumors (

Indexed as

ProteomeProteomicsRadiation ToleranceRectal NeoplasmsAdultAgedBiomarkers, TumorFemaleFormaldehydeGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoadjuvant TherapyParaffin EmbeddingPrognosisBiomarkers, TumorFormaldehydeProteomeautophagic activitycolorectal cancerDNA damage repairFFPE tissueLC-MSproteome profilingradioresistanceradiotherapyresistance mechanismstumor-associated stroma

Identifiers

PMID40574313
PMCPMC12322959

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.