Evidence map›Paper›PMID 40574362›Full record

ReviewCurrent cardiology reviews2026

A Bibliometric Analysis of P2X7R in Cardiovascular Diseases from 2005 to 2024.

Juanjuan Tan, Wenqi Zhou, Zhiye Guo, Li Cheng, Yalong Kang, Qiong Wang, Jing Dong, Haifang Wang, Qi Zhang, Li Shen and 1 more

Abstract readReview
In one paragraph

Review in Current cardiology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juanjuan TanInstitute of Integrative Medicine, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Wenqi ZhouThe Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, 712083, China.
Zhiye GuoInstitute of Mechanobiology & Medical Engineering, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang, 200240, Shanghai, China.
Li ChengThe Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, 712083, China.
Yalong KangShaanxi Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases, Shaanxi University of Chinese Medicine, Xianyang, 712083, China.
Qiong WangDepartment of Cardiology, The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, China.
Jing DongShaanxi University of Chinese Medicine Affiliated Hospital, Xianyang, 712000, China.
Haifang WangShaanxi Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases, Shaanxi University of Chinese Medicine, Xianyang, 712083, China.
Qi ZhangShaanxi Key Laboratory of Chinese Medicine Encephalopathy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Li ShenCardiology Department, The Third Hospital of Changsha, Changsha, 413000, China.
Kai HuangInstitute of Mechanobiology & Medical Engineering, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang, 200240, Shanghai, China.

Funding

National Natural Science Foundation of China 12302409, 82074380Shaanxi Provincial Department of Science and Technology's Basic Research Program 2023-JC-QN-0853Xianyang City Integrated Traditional Chinese and Western Medicine Research on Inflammatory Diseases Innovation Team L2022CXNLTD003Xianyang City Key Research and Development Plan Project L2022ZDYFSF009
6 · The paper itself

Abstract

introductionThe P2X7 receptor (P2X7R), which mediates inflammation, is implicated in an extensive variety of diseases, including cardiovascular dysfunction. Recently, studies focusing on the role of P2X7R in cardiovascular disorders have garnered significant attention. However, a bibliometric evaluation within this area has yet to be carried out.

methodsA bibliometric analysis was performed by searching for research related to P2X7R and cardiovascular diseases in the Web of Science Core Collection (WoSCC) database from 2005 to 2024. The tools CiteSpace and VOSviewer were utilized to analyze data and create visual representations of various elements, including countries, institutions, authors, journals and keywords.

resultsOver the past two decades, 371 articles in English were obtained in the last 20 years. The People's Republic of China, Nanchang University, the journal 'Purinergic Signalling,' and author Shandong Liang had the highest productivity in their respective categories. The top 4 keywords were ''activation',' ''p2x7 receptor',' ''ATP',' and ''inflammation''. Burst keyword analysis indicated that ''purinergic signaling'' and ''oxidative stress'' are emerging key areas worthy of further investigation. These topics, seeing a surge in interest, are predicted to remain prominent in research. DISCUSSION: This is the first bibliometric analysis of P2X7R in cardiovascular disorders, which reports the hot spots and emerging trends. The interaction between ''purinergic signaling'', ''inflammation'', and ''oxidative stress'' are considered to be the current research priorities, suggesting that these topics are likely to remain central in future research.

conclusionThis study underscores the growing importance of P2X7R in cardiovascular research and offers valuable insights to guide future investigations.

Indexed as

BibliometricsCardiovascular DiseasesReceptors, Purinergic P2X7HumansReceptors, Purinergic P2X7bibliometric analysiscardiovascular diseaseCiteSpaceP2X7Rpurinergic signaling.VOSviewer

Identifiers

PMID40574362
PMCPMC12976433

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.