Evidence map›Paper›PMID 40574365›Full record

ArticleCurrent pharmaceutical design2026

Anticandidal Effects of

Saurabh Gupta, Lokesh Nagar, Madhav Singla, Smriti, Sachin Kumar Singh, Gaurav Gupta, Suresh Bhojraj, Rahamat Unissa Syed, Aliaa Alshammari, Maali D Alshammari and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Current pharmaceutical design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Ethnobotany, Phytochemistry, and Pharmacological Activities ofInternational journal of molecular sciences · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Saurabh GuptaDepartment of Pharmacology, Chameli Devi Institute of Pharmacy, Khandwa Road, Village Umrikheda, Near Toll Booth, Indore, Madhya Pradesh, 452020, India.
Lokesh NagarDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
Madhav SinglaChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.
SmritiChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.
Sachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Gaurav GuptaCentre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Suresh BhojrajDepartment of Pharmacology, J.S.S. College of Pharmacy (Off Campus JSS University), Ootacamund, 643 001, TN, India.
Rahamat Unissa SyedDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.
Aliaa AlshammariDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.
Maali D AlshammariDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.
Njoud Nahi Omer AlshammariCollege of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.
Atheer Nahi Omer AlshammariCollege of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.
Entsar Mohammed AlhaidanCollege of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.

Funding

Scientific Research Deanship at University of Ha'il - Saudi Arabia RG-23 078
6 · The paper itself

Abstract

backgroundThis research explored the antimicrobial, antifungal, and in vivo anticandidal activities of two herbal extracts:

aimTo examine the efficacy of HEOB and HEOS extracts in terms of their antimicrobial, antifungal, and anti-candidal activities and analyze their phytochemical composition, antioxidant potential, and immunomodulatory properties in vivo.

methodsDried flowers and leaves from

resultsHEOB and HEOS extracts possess strong antimicrobial and antioxidant activities, largely due to flavonoids such as rutin, quercetin, rosmarinic acid and eugenol. In vivo experiments revealed that both extracts effectively reduced fungal load, increased survival rates, and alleviated immunosuppression in mice with systemic candidiasis. The extracts also exhibited significant immunomodulatory properties by boosting cellmediated immune responses. At higher concentrations, the antifungal performance of HEOB and HEOS was similar to that of ketoconazole.

conclusionHEOB and HEOS exhibited strong antibacterial, antifungal, and anticandidal properties, showing significant effectiveness in treating systemic candidiasis. Their immunomodulatory effects and ability to boost cell-mediated immunity make these extracts promising options for addressing systemic candidiasis, particularly in individuals with weakened immune systems. This research offers valuable insights and sets the stage for future investigations into the treatment of oral and vaginal candidiasis.

Indexed as

Antifungal AgentsCandida albicansCandidiasisOcimum basilicumOcimum sanctumPlant ExtractsAnimalsAntioxidantsMiceMicrobial Sensitivity TestsAntifungal AgentsAntioxidantsPlant Extractsantibacterial.candidiasisimmunocompromisedOcimum basilicumOcimum sanctumquercetinrutin

Identifiers

PMID40574365

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.