Evidence map›Paper›PMID 40574367›Full record

ReviewCurrent pharmaceutical design2026

TSIX: A Novel Long Noncoding RNA in Cancer Development and Progression.

Yibei Gui, Jiale Zhao, Wei Wu, Xueqing Li, Lijun Wang, Hailin Wang, Yiyang Luo, Xueliang Ding, Xiaolan Li, Chengfu Yuan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yibei GuiHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.
Jiale ZhaoHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.
Wei WuHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.
Xueqing LiHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.
Lijun WangHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.
Hailin WangHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.
Yiyang LuoHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.
Xueliang DingDepartment of Clinical Laboratory, Affiliated Renhe Hospital of China Three Gorges University, Yichang, 443001, China.
Xiaolan LiThe Second People's Hospital of China Three Gorges University, Yichang, 443002, China.
Chengfu YuanHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yicheng, 443002, China.

Funding

National Natural Science Foundation of China 82174035, 82374107Scientific Research Project on Traditional Chinese Medicine of Hubei Provincial Administration of Traditional Chinese Medicine ZY2025D023
6 · The paper itself

Abstract

Long noncoding RNAs (LncRNAs) represent a group of long noncoding RNA molecules exceeding 200 nt in length and lacking the capacity for protein coding. In recent years, the function and progress of lncRNA have attracted the attention of more and more researchers. Specifically, the long non-coding RNA, TSIX (TSIX transcript, XIST antisense RNA), plays a significant role in ensuring random X-chromosome inactivation. Recent investigations have highlighted the involvement of lncRNA TSIX in the development of various cancers, emphasizing its crucial functions in tumorigenesis. TSIX has emerged as a novel cancerassociated lncRNA and it is identified for its aberrant expression in diverse tumors, such as those of the breast, gastric, hepatocellular, head and neck, lung, esophageal squamous cell, and uterine smooth muscle. Furthermore, lncRNA TSIX regulates mRNA expression by binding to specific miRNAs, utilizing a competitive endogenous RNA regulatory mechanism. This interaction significantly influences tumor cell proliferation, migration, invasion, and apoptosis. LncRNA TSIX may serve as a useful biomarker or a prospective therapeutic target in a variety of malignant cancers because of the biological functions and mechanisms associated with it.

Indexed as

NeoplasmsRNA, Long NoncodingAnimalsCell ProliferationDisease ProgressionHumansRNA, Long Noncodingbiomarkers.cancersLncRNA TSIXlong non-coding RNAmolecular mechanismtumorigenesis

Identifiers

PMID40574367

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.