ReviewEuropean heart journal2025
Medial arterial calcification in ageing and disease: current evidence and knowledge gaps.
Review in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Review
- Enigma of medial coronary artery calcifications: an unfolding story.European heart journal open · 2026Article
- Pathological Insights Into the Relationship Between Medial and Intimal Calcification in Lower Extremity Artery Disease.JACC. Advances · 2026Article
- Cellular Heterogeneity During Arterial Aging.Aging cell · 2026Review
- Factors Associated With Below-the-Ankle Lesions and Their Impact on Clinical Outcomes Following Revascularization in Chronic Limb-Threatening Ischemia.Circulation reports · 2026Article
- Coronary Artery Calcification: From Molecular Mechanisms to Interventional Strategies.International journal of molecular sciences · 2026Review
- Medial arterial calcification and refractory osteomyelitis in systemic sclerosis: a case report and literature review.Internal and emergency medicine · 2026Article
- From Mechanism to Therapy: Establishing an Integrated Framework for the Regulation and Intervention of Matrix Vesicles in Vascular Calcification.Cardiovascular drugs and therapy · 2026Review
- A robust endothelial injury model inducing medial arterial calcification in C57BL/6J mice on a standard diet.Cardiovascular diagnosis and therapy · 2026Article
- Considerations in the Use of Mouse Models of Vascular and Valvular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Mechanisms of vascular calcification: cellular phenotype switching drives matrix remodeling and mineralized microenvironment formation.Frontiers in cardiovascular medicine · 2026Review
- The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential.Frontiers in cardiovascular medicine · 2026Review
- New Bioinformatic Insight into CD44: Classification of Human Variants and Structural Analysis of CD44 Targeting.International journal of molecular sciences · 2025Article
- Construction of a diagnostic model and identification of effect genes for diabetic kidney disease with concurrent vascular calcification based on bioinformatics and multiple machine learning approaches.Frontiers in molecular biosciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Medial arterial calcification (MAC) characterizes human arterial ageing, potentially remaining clinically silent for decades. However, in susceptible individuals and patients with diabetes mellitus and chronic kidney disease, it becomes a critical risk factor for cardiovascular morbidity and mortality, and it is a significant risk factor for chronic limb-threatening ischaemia and limb amputation. A key biological feature of MAC pathogenesis is the phenotype switching of vascular smooth muscle cells, ultimately responsible for the deposition of hydroxyapatite crystals and the progressive medial layer destruction associated with intimal thickening. The signalling pathways targeting the vascular smooth muscle cells in ageing and disease are partly shared. Due to the MAC-related arterial wall stiffening and intimal thickening, MAC fundamentally alters central and peripheral haemodynamics. Yet, a comprehensive understanding of MAC's impact on haemodynamics is lacking. Ankle-brachial index, ultrasound, and X-ray radiography can detect only advanced MAC in the clinical setting. Due to the slow progression, MAC provides many early detection, prevention, and timely intervention targets. However, no effective pharmacological treatment is currently available to alter its course, and revascularizations remain the only treatment option in symptomatic patients. To prevent, reverse, or delay MAC, further research is needed to reveal the complete picture of molecular pathogenesis and haemodynamic impact of MAC vasculopathy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.