Evidence map›Paper›PMID 40575116›Full record

ArticleJournal of Alzheimer's disease reports

Insights into the role of cerebrospinal fluid cytokines in Alzheimer's disease: A commentary on recent findings.

Carlo Manco, Matteo Pardini, Delia Righi, Domenico Plantone

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Challenge-based ex vivo immune profiling reveals stimulus-dependent peripheral immune reprogramming in Alzheimer's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlo MancoDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0003-4572-2616
Matteo PardiniDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Delia RighiDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Domenico PlantoneDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We read the study by Bruno et al. (2025), which highlights the interplay between neuroinflammation and cortical activity in Alzheimer's disease (AD). Their findings on IL-4, IL-7, IL-8, and IL-12 levels and their association with EEG alterations complement our recent research on IL-6, GDF-15, and neuronal damage. We discuss the implications of IL-8 in blood-brain barrier permeability and neurodegeneration, the role of

Indexed as

Alzheimer's diseaseepilepsyinterleukinsneuroinflammation

Identifiers

PMID40575116
PMCPMC12198534

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.