ReviewFrontiers in endocrinology2025
Secretion of placental peptide hormones: functions and trafficking.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- Review
- Placenta-Derived Extracellular Vesicles (pdEVs): Key Mediators That Affect the Metabolic Health of Offspring in Early Nutritional Environments.Biomolecules · 2026Review
- Comprehensive Analysis of the Placenta-Cortex Transcriptomic Database Reveals a Neuroactive Ligand-Receptor Dysregulation After Prenatal Alcohol Exposure.International journal of molecular sciences · 2026Article
- Maternal Poly (I:C)-Induced Placental Inflammation and Endocrine Dysfunction Are Associated with Disrupted Corticogenesis in Mouse Offspring.Brain sciences · 2026Article
- Editorial: Physiology and pathophysiology of placenta.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The placenta is a dynamic endocrine organ that plays a crucial role in fetal development by secreting a diverse array of peptide hormones that regulate maternal and fetal physiology. These hormones, including human chorionic gonadotropin (hCG), human placental lactogen (hPL), and placental growth hormone (hPGH), among others, are essential for pregnancy maintenance, fetal growth, and metabolic adaptation. Dysregulation of the secretory machinery and the levels of these hormones in circulation is associated with a myriad of pregnancy-related disorders. Despite their significance, the mechanisms governing their intracellular trafficking and secretion remain incompletely understood. This review synthesizes current knowledge on the secretion pathways of placental hormones, highlighting the interplay between constitutive and regulated secretion, and the challenges in defining these mechanisms due to the unique structure of the syncytiotrophoblast. We also discuss how emerging technologies, such as 2D and 3D placental models and advanced protein trafficking assays, can provide deeper insights into the regulation of placental hormone secretion. Understanding these processes will not only enhance our knowledge of placental biology but also provide new avenues for diagnosing and treating pregnancy-related disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.