Evidence map›Paper›PMID 40575348›Full record

ArticleStem cells international2025

Isolate Circulating Mesenchymal Stromal Cells Without Growth Factor Administration and Using Density Gradient.

Jason Ma, Chung-Chuan Hsiung, Tzu-Hsien Yang, Hsiu-Yen Sun, Ming-Ling Kuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jason MaDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan (ROC).ORCID https://orcid.org/0009-0005-3965-5674
Chung-Chuan HsiungDepartment of Medical Trial, Bo-ai Clinic, Kaohsiung, Taiwan (ROC).ORCID https://orcid.org/0009-0005-7451-3014
Tzu-Hsien YangDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan (ROC).ORCID https://orcid.org/0009-0004-3882-3050
Hsiu-Yen SunDepartment of Medical Trial, Bo-ai Clinic, Kaohsiung, Taiwan (ROC).ORCID https://orcid.org/0009-0009-8026-7293
Ming-Ling KuoDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan (ROC).ORCID https://orcid.org/0000-0003-1959-4972

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) are recognized for their differentiation and immune regulation capabilities, which enhance their potential for treating various diseases. MSCs can be sourced from diverse tissues, with peripheral blood (PB) serving as a viable alternative to bone marrow. We now present an alternative strategy that eliminates the need for preadministering growth factors, utilizing density gradient methods, and culturing target cells in medium supplemented with autologous serum. PB was collected through venipuncture and then coincubated with glycerin. After incubation, a thin layer of cells above the red blood cells (RBCs) was isolated, showing an increased population of CD34

Indexed as

differentiationimmunomodulatory abilitiesmesenchymal stromal cellsperipheral blood

Identifiers

PMID40575348
PMCPMC12202064

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.