Evidence map›Paper›PMID 40575402›Full record

ArticleRespirology case reports2025

A Case of PMR-Like irAE Developing After Treatment With Ipilimumab and Nivolumab for Lung Cancer.

Ryuichi Utsumi, Hideki Terai, Tetsuya Arai, Yu Iwabuchi, Mitsuhiro Akiyama, Shigenari Nukaga, Keiko Ohgino, Hiroki Kabata, Shotaro Chubachi, Hiroyuki Yasuda and 1 more

Abstract read
In one paragraph

Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryuichi UtsumiDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.
Hideki TeraiDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0002-1118-1930
Tetsuya AraiDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.
Yu IwabuchiDepartment of Radiology Keio University School of Medicine Tokyo Japan.
Mitsuhiro AkiyamaDivision of Rheumatology, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.
Shigenari NukagaDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.
Keiko OhginoDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.
Hiroki KabataDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0001-8853-6149
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.
Hiroyuki YasudaDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Internal Medicine Keio University School of Medicine Tokyo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune-checkpoint inhibitors (ICIs) have become one of the main strategies for advanced cancers. ICIs are associated with many immune side effects, called immune-related adverse events (irAEs). Since irAE has various variations, it is important to carefully examine each individual case that develops irAE. We experienced a case of polymyalgia rheumatica (PMR)-like irAE after three courses of administration of Ipilimumab and Nivolumab for stage IV lung adenocarcinoma. We also confirmed that the activity of this irAE was detectable on the PET-CT scan performed to assess lung cancer progression. Given the limited reports of PMR-like irAE occurring after treatment with two immune checkpoint inhibitors, we present this case along with a review of the literature.

Indexed as

immune‐checkpoint inhibitorimmune‐related adverse eventlung cancerpolymyalgia rheumatica

Identifiers

PMID40575402
PMCPMC12197867

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.