Evidence map›Paper›PMID 40575431›Full record

ArticleWorld journal of cardiology2025

Hydrogen alleviates right ventricular hypertrophy by inhibiting ferroptosis

Jun-Cai Bai, Hong-Xiao Yang, Cheng-Chuang Zhan, Lu-Qi Zhao, Jia-Ren Liu, Wei Yang

Abstract read
In one paragraph

Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun-Cai BaiDepartment of Cardiology, Zhengzhou University Affiliated Zhengzhou Central Hospital, Zhengzhou 450000, Henan Province, China.
Hong-Xiao YangDepartment of Cardiology, Zhengzhou University Affiliated Zhengzhou Central Hospital, Zhengzhou 450000, Henan Province, China.
Cheng-Chuang ZhanDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China.
Lu-Qi ZhaoDepartment of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
Jia-Ren LiuDepartment of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
Wei YangDepartment of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China. weiyangyangwei@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight ventricular hypertrophy (RVH) occurs because of volume or pressure overload within the right ventricular (RV) system. RVH is associated with complex pathological changes, including myocardial cell injury, apoptosis, myocardial fibrosis, neuroendocrine disturbances, and abnormal water and liquid metabolism. Ferroptosis, a novel type of iron-dependent cell death characterized by lipid peroxide accumulation, is an important mechanism of cardiomyocyte death. However, the role of ferroptosis in RVH has rarely been studied. We hypothesize that hydrogen (H

aimTo explore the protective effect of H

methodsAn

resultsIn MCT-treated rats, H

conclusionH

Indexed as

FerroptosisHydrogenNrf2/HO-1Right ventricular hypertrophy

Identifiers

PMID40575431
PMCPMC12186143

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.