Evidence map›Paper›PMID 40575462›Full record

ArticleFrontiers in chemistry2025

Alkhair Adam Khalil Mohamed, Isaac Asiamah, Ghazi Elamin, James Darkwa, Christian K Adokoh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alkhair Adam Khalil MohamedDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Isaac AsiamahDepartment of Chemistry, School of Physical Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.
Ghazi ElaminDepartment of Pharmaceutical Chemistry, College of Pharmacy, Karary University, Khartoum, Sudan.
James DarkwaDepartment of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa.
Christian K AdokohDepartment of Forensic Science, School of Biological Sciences, College of Agriculture and Natural Sciences University of Cape Coast, Cape Coast, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study employed in silico methods to investigate the anticancer potential and mechanisms of twenty novel phosphinogold(I) thiocarbohydrate complexes. Methods: Molecular docking and Prime MM-GBSA screening of seventeen cancer-related protein targets, including Human Double Minute 2 protein (HDM2), DNA methyltransferase-1 (DNMT1), Protein Kinase B (AKT2), and Poly (ADP-ribose) polymerase 1 (PARP-1), were conducted. Molecular dynamics simulations were performed for complex Results: Virtual screening revealed strong binding affinities for several complexes, often surpassing native ligands. All the complexes except Discussion: These findings provide valuable insights into multi-target anticancer mechanisms, with a particular emphasis on complex Conclusion: The paradoxical effect of acetylation underscores the importance of balancing lipophilicity and binding strength in ligand design.

Indexed as

anticancer activitycytotoxicityMM-GBSAmolecular dockingstructure activity relationshipthiocarbohydrate Phosphinogold(I) complexes

Identifiers

PMID40575462
PMCPMC12198200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.