Evidence map›Paper›PMID 40575620›Full record

ArticleSleep advances : a journal of the Sleep Research Society2025

Association of nocturnal hypoxemia and white blood cell count in a multicenter cohort.

Aditi Shah, Mohammadreza Hajipour, A J Hirsch Allen, Najib Ayas, Tetyana Kendzerska, Patrick Hanly, John Kimoff, Frederic Series, Annie Lajoie, Rebecca Robillard and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aditi ShahDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Brititsh Columbia, Canada.
Mohammadreza HajipourDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Brititsh Columbia, Canada.
A J Hirsch AllenDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Brititsh Columbia, Canada.
Najib AyasDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Brititsh Columbia, Canada.
Tetyana KendzerskaDivision of Respiratory Medicine, Department of Medicine, Faculty of Medicine, University of Ottawa/The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0002-5301-1796
Patrick HanlyHotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
John KimoffRespiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, Quebec, Canada.
Frederic SeriesCentre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ-UL), Quebec City, Quebec, Canada.ORCID https://orcid.org/0000-0003-0851-5765
Annie LajoieCentre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ-UL), Quebec City, Quebec, Canada.
Rebecca RobillardSchool of Psychology, University of Ottawa, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0002-1491-997X
Rachel JenDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Brititsh Columbia, Canada.
Andrew E BeaudinHotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0002-3295-7232
Jill RaneriSleep Centre, Foothills Medical Centre, Calgary, Alberta, Canada.
Robert SkomroDepartment of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study Objectives: There is a higher risk of cardiovascular disease (CVD) in patients with obstructive sleep apnea (OSA) and innate immunity is a potential pathophysiologic pathway. The objective of this study was to determine whether nocturnal hypoxemia is associated with circulating markers of innate immunity in OSA. Methods: This was a cross-sectional study of an observational cohort from the multicentre, clinic-based, Canadian Sleep and Circadian Network. Oxygen desaturation index 4% (ODI4%) was used to diagnose and determine the severity of OSA. The percentage of time spent below SpO Results: A total of 1296 patients were included in the analysis. There was a positive association between ODI4% and lymphocyte count, adjusting for confounders. For every 1- Conclusions: In this pan-Canadian clinic-based cohort of individuals with suspected OSA, nocturnal hypoxemia indices were associated with an increase in total WBC and subset counts.

Indexed as

biomarkershypoxiasleep-disordered breathing

Identifiers

PMID40575620
PMCPMC12198955

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.