Evidence map›Paper›PMID 40575636›Full record

ArticleWorld journal of virology2025

Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals.

Mohamed A Abdelrazek, Ahmed I Elghwab, Ashraf A Tabll, Elsherbiny H Elsayed, Mohammed El Behery

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Article in World journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamed A AbdelrazekDepartment of Research and Development, Biotechnology Research Center, New Damietta 34517, Egypt.
Ahmed I ElghwabDepartment of Chemistry, Faculty of Science, Port Said University, Port Said 8525502, Egypt.
Ashraf A TabllDepartment of Microbial Biotechnology, National Research Centre, Dokki 12622, Egypt.
Elsherbiny H ElsayedDepartment of Chemistry, Faculty of Science, Port Said University, Port Said 8525502, Egypt.
Mohammed El BeheryDepartment of Chemistry, Faculty of Science, Port Said University, Port Said 8525502, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment response to direct-acting antivirals (DAAs) is a challenging issue and the identification of non-responders patients is very important.

aimTo evaluate the relation between baseline serum levels of hyaluronic acid (HA) and type III procollagen N-peptide (PIIINP) with direct-acting antivirals treatment failure in Egyptian patients with chronic hepatitis C.

methodsHepatitis C patients (responders and non-responders to sofosbuvir/daclatasvir) were tested for HA and PIIINP using sensitive chemiluminescent immunoassay.

resultsThere were distinctly higher PIIINP (

conclusionThese findings suggested the remarkable role of fibrogensis markers HA and PIIINP in the prediction of hepatitis C virus DAAs treatment response. Multiplying HA with PIIINP values increase the sensitivity to detect treatment success and thus may aim to improve treatment duration and the disease control.

Indexed as

Fibrogensis markersHepatitis C virusHyaluronic acidTreatment responseType III procollagen N-peptide

Identifiers

PMID40575636
PMCPMC12188855

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.