ArticleSafety and health at work2025
Association Between Shift Working and Brain Morphometric Changes in Workers: A Voxel-wise Comparison.
Article in Safety and health at work, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Occupational circadian disruption and brain structure: evidence from normative developmental brain lifespan trajectories.Brain structure & function · 2026Article
- Circadian disruption and circulating TGF-β1 in workers: evidence from Mendelian randomization and observational data.Frontiers in immunology · 2026Observational
- Altered functional network topology and connectivity in female nurses with shift work sleep disorder.Frontiers in systems neuroscience · 2025Article
- Association between shift work and brain age gap: a neuroimaging study using MRI-based brain age prediction algorithms.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: There is abundant evidence from observational studies linking various health problems to shift work, but there is a lack of brain-based neurological evidence. Therefore, we examined morphometric changes on brain magnetic resonance imaging (MRI) between shift and non-shift workers. Methods: A total 111 healthy workers participated in this study and underwent brain MRI, with the analysis incorporating merged workers' health surveillance data from regional hospital workers. Voxel-based morphometry analysis was used to investigate regional changes in the gray matter volume. To investigate the association of structural changes between shift workers and non-shift workers, a general linear model and threshold-free cluster enhancement were used with covariates, including total intracranial volume, age, and sex. Results: After family-wise error correction, non-shift workers exhibited a significantly larger cerebellar region ( Conclusions: We observed increased clusters in the brains of both shift and non-shift workers, suggesting that the acquired occupational environment, including the shift work schedule, could influence brain neuroplasticity, which is an important consideration for occupational health.
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Registered trials
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