Evidence map›Paper›PMID 40576333›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Early Increase in Weight Is Seen During Treatment for Paediatric Acute Lymphoblastic Leukaemia-A Retrospective Analysis of Medical Records.

Håkon Endal, Bjørn Helge Handegård, Katrine Nordeng Mellem, Anita Andrejeva, Inga Maria Rinvoll Johannsdottir, Bendik Lund, Trond Flægstad, Inger P Landsem

Abstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Håkon EndalInstitute of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0002-7615-0086
Bjørn Helge HandegårdRegional Centre for Child and Youth Mental Health and Child Welfare, UiT The Arctic University of Norway, Tromsø, Norway.
Katrine Nordeng MellemInstitute of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Anita AndrejevaDepartment of Paediatric Oncology, Haukeland University Hospital, Bergen, Norway.
Inga Maria Rinvoll JohannsdottirDepartment of Paediatric Haematology and Oncology, Oslo University Hospital, Oslo, Norway.
Bendik LundDepartment of Paediatric Haematology and Oncology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Trond FlægstadInstitute of Clinical Medicine, UiT The Arctic University of Norway, The University Hospital of Northern Norway, Division for Paediatric Haematology and Oncology, Tromsø, Norway.
Inger P LandsemInstitute of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, Norway.

Funding

Thorfinns Memorial Fund for Cancer research 62427
6 · The paper itself

Abstract

aimThe aim of the study was to assess growth patterns in a national cohort of children aged 0-17.9 years diagnosed with acute lymphoblastic leukaemia (ALL).

methodsMedical records at the four tertiary paediatric oncology hospitals in Norway were used for retrospective data collection. Anthropometrics were collected for patients diagnosed between 1 January 2008 and 31 December 2018, weekly, or as soon after as available, and followed up for 10 years after diagnosis. Z-scores were collected from the growth curve function in the medical record software and compared to the Norwegian reference population. Generalised additive mixed model was used for analysis.

resultsThe analysis included 375 paediatric ALL patients. Data displayed an initial weight loss (z-score from 0.00 to -0.25) and a stagnation in height growth (z-score from 0.20 to -0.55). Throughout treatment and into remission, weight and body mass index stabilised significantly above the average healthy population (z-score: 0.30 and 0.55 respectively). Height was nonsignificantly different in remission compared to the general population (z-score: -0.15).

conclusionWeight gain, and BMI increase, occurred earlier than previously reported. Height was negatively affected by treatment. Monitoring of nutritional status, nutritional support efforts and physical activity is important throughout treatment to prevent unwanted and avoidable fluctuations in growth.

Indexed as

Precursor Cell Lymphoblastic Leukemia-LymphomaWeight GainAdolescentBody HeightBody Mass IndexChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleNorwayRetrospective Studiesanthropometricsbody mass indexgeneralised additive mixed modelsoncologypaediatric

Identifiers

PMID40576333
PMCPMC12520275

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.