Evidence map›Paper›PMID 40576344›Full record

ArticlemBio2025

Transposon insertion sequencing reveals novel hypermutator genes in

Francesca L Short, Ram Maharjan, Liping Li, Nusrat Afrin, Natasha Delgado, Christine J Boinett, Julian Parkhill, Amy K Cain, Ian T Paulsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca L ShortDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-0025-4858
Ram MaharjanARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Liping LiARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Nusrat AfrinARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Natasha DelgadoARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Christine J BoinettWellcome Sanger Institute, Hinxton, United Kingdom.
Julian ParkhillWellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0002-7069-5958
Amy K CainARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Ian T PaulsenARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0001-9015-9418

Funding

Australian Research Council DE180100929, FT220100152Australian Research Council DE200101524Australian Research Council FL140100021, CE200100029National Health and Medical Research Council APP11200298Wellcome TrustWellcome Trust WT098051
6 · The paper itself

Abstract

Mutation rates in bacteria are an important determinant of adaptation to new environments and success in different niches. In some bacterial pathogens, "hypermutator" variants-most often associated with mutations in components of the DNA mismatch repair system-are associated with increased antibiotic resistance and poorer patient outcomes. We report the serendipitous finding of novel hypermutator genes in

Indexed as

Acinetobacter baumanniiDNA Transposable ElementsGenes, BacterialMutagenesis, InsertionalAnti-Bacterial AgentsBacterial ProteinsGenome, BacterialMutationMutation RateAnti-Bacterial AgentsBacterial ProteinsDNA Transposable ElementsAcinetobacterhypermutatormutation ratetn-seqtradis

Identifiers

PMID40576344
PMCPMC12345246

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.