ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025
Protective effects of tasimelteon on kidney injury in a traumatic brain injury rat model: a histopathological and immunohistochemical study.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Melatonin Administration Attenuates High-Fat-Diet-Induced Renal Damage in Wistar Rats.Biomolecules · 2025Article
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Abstract
purposeTraumatic brain injury (TBI) is a condition characterized by structural and functional damage to the brain following trauma and is a significant cause of mortality. Acute kidney injury (AKI) has been reported in patients with TBI and is a commonly encountered complication. This study examines the effect of tasimelteon (Tasi) application on kidney tissue in TBI rats by histopathological and immunohistochemical staining.
methodsForty male Wistar Albino rats weighing 300–350 g were randomly divided into four groups: Control group, Trauma group (Trau), Trau-Tasi-1 group (trauma-1 mg/kg Tasi intraperitoneally), and Trau-Tasi-10 group (trauma-10 mg/kg Tasi intraperitoneally). At the end of the experimental phase, after euthanasia, kidney tissue was collected for histopathological and immunohistochemical analyses.
resultsThe results of histopathological and immunohistochemical staining demonstrate that brain trauma may induce kidney injury, while Tasi possesses the potential to ameliorate kidney lesions associated with TBI. It has been found that Trau-Tasi-10 is more effective in treatment compared to Trau-Tasi-1.
conclusionWe observed Tasi’s kidney injury ameliorating activity in TBI rats through histopathological and immunohistochemical staining findings.
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