Evidence map›Paper›PMID 40577056›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition.

Cristina Sáenz de Miera, Nicole Bellefontaine, Marina A Silveira, Chelsea N Fortin, Thais T Zampieri, Jose Donato, Kevin W Williams, Cristiano Mendes-da-Silva, Laura Heikkinen, Christian Broberger and 2 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Cristina Sáenz de MieraDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-8047-035X
Nicole BellefontaineDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
Marina A SilveiraDepartment of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.ORCID https://orcid.org/0000-0002-8351-5549
Chelsea N FortinDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.
Thais T ZampieriDepartment of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-1611-354X
Jose DonatoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-4166-7608
Kevin W WilliamsCenter for Hypothalamic Research, Department of Internal Medicine, Peter O'donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-8434-8658
Cristiano Mendes-da-SilvaDepartment of Biosciences, Federal University of Sao Paulo, Santos, Brazil.ORCID https://orcid.org/0000-0001-7027-0127
Laura HeikkinenDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Christian BrobergerDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7050-8809
Renata FrazaoDepartment of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-0877-8453
Carol F EliasDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-9878-9203

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
Ventromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2019 to 2023
$10.0M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
Metabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK135066 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias · 2023 to 2026
$3.5M
Neural basis of leptin action on reproductionR01HD069702 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI ELIAS, CAROL FUZETI · 2012 to 2021
$3.4M
Sex-specific role of androgen signaling in neuroendocrine-behavior interfaceR01HD106962 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias · 2023 to 2026
$1.7M
Cellular and Synaptic Reorganization after Exercise TrainingR01DK119169 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2018 to 2021
$1.6M
Leica SP8 Confocal MicroscopeS10OD028612 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANTONETTI, DAVID · 2021 to 2021
$599k
Prenatal photoperiod action in hypothalamic developmentR21HD109485 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2022 to 2023
$429k
Acute and chronic effects of GLP-1R agonism on NPY/AgRP neuronal activityR56DK135501 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2024 to 2024
$410k
Coordenação de Aperfeiçoamento de Pessoal de Novel Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 13/079088Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 15/201985HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01 HD 069702HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P01DK119130-03HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30DK020572HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) S10OD028612-01-A1Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2020.0054NICHD NIH HHS R01 HD069702NICHD NIH HHS R01 HD106962NICHD NIH HHS R21 HD109485NIDDK NIH HHS P01 DK119130NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK119169NIDDK NIH HHS R56 DK135501NIDDK NIH HHS U2C DK110768NIDDK NIH HHS U2C DK135066NIH HHS S10 OD028612Swedish Research Council 2021 00671
6 · The paper itself

Abstract

Pubertal development is tightly regulated by energy balance. The crosstalk between metabolism and reproduction is orchestrated by complex neural networks, and leptin action in the hypothalamus plays a critical role. The ventral premammillary nucleus (PMv) leptin receptor (LepRb) neurons act as an essential relay for leptin action on reproduction. Here, we show that mouse PMv cells expressing the dopamine transporter (DAT) gene, Slc6a3 (PMv

Indexed as

Dopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsHypothalamus, AnteriorNeuronsSexual MaturationAnimalsFemaleKisspeptinsLeptinMaleMiceMice, Inbred C57BLReceptors, LeptinDopamine Plasma Membrane Transport ProteinsKisspeptinsLeptinReceptors, Leptindopamine transporterhypothalamusKiss1leptinnutritionpuberty

Identifiers

PMID40577056
PMCPMC12204309

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.