Observational studyAmerican journal of hypertension2025
Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort.
Observational study in American journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Relationship between medication class and ambulatory blood pressure profile in the chronic renal insufficiency cohort (CRIC) study.Journal of human hypertension · 2026Article
- Dose-Response Effects of Different Exercise Modalities on Blood Pressure Control in Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis.Life (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPatients with chronic kidney disease (CKD) have abnormal blood pressure patterns which may affect 24-hour ambulatory blood pressure variability (ABPV). However, little is known about the association between ABPV and adverse outcomes among those with CKD.
methodsUsing data from the Chronic Renal Insufficiency Cohort (CRIC) Study, we assessed 24-hour, daytime, and nighttime systolic ABPV using average real-time variability (ARV); the sum of the absolute differences between consecutive blood pressure readings divided by the total number of readings minus one. Cox proportional hazard models were used to evaluate the association of ARV with a 50% reduction in estimated glomerular filtration rate or end-stage kidney disease or adverse cardiovascular (CV) events.
resultsOf 1,502 CRIC participants included in this analysis, 44% were female, and the mean age was 63 ± 10 years. Factors associated with higher tertile of ARV included older age, higher body mass index, higher urine protein-to-creatinine ratio, lower estimated glomerular filtration rate, diabetes, hypertension, dyslipidemia, and atherosclerotic heart disease. In unadjusted models, 24-hour systolic ARV was associated with both adverse kidney outcomes (hazard ratio (HR): 1.16, 95% confidence interval (CI): 1.06-1.27) and CV events (HR: 1.35, 95% CI: 1.22-1.50). In adjusted models that included clinical and sociodemographic factors, 24-hour systolic ARV was not significantly associated with adverse kidney outcomes (HR: 1.02, 95% CI: 0.91-1.14) or CV events (HR: 0.93, 95% CI: 0.84-1.04). Similarly, daytime and nighttime ARV were not significantly associated with kidney and CV events in adjusted analyses.
conclusionsIn a large cohort of patients with CKD, ABPV was not independently associated with adverse kidney and CV outcomes.
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