Evidence map›Paper›PMID 40577588›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Bacterial Minicell-Based Biohybrid Sub-micron Swimmers for Targeted Cargo Delivery.

Saadet Fatma Baltaci, Mukrime Birgul Akolpoglu, Irina Kalita, Victor Sourjik, Metin Sitti

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bacterial Minicell-Based Biohybrid Sub-micron Swimmers for Targeted Cargo Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saadet Fatma BaltaciPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.ORCID https://orcid.org/0000-0002-6214-3272
Mukrime Birgul AkolpogluPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Irina KalitaMax Planck Institute for Terrestrial Microbiology and Center for Synthetic Microbiology (SYNMIKRO), School of Medicine and College of Engineering, 35043, Marburg, Germany.
Victor SourjikMax Planck Institute for Terrestrial Microbiology and Center for Synthetic Microbiology (SYNMIKRO), School of Medicine and College of Engineering, 35043, Marburg, Germany.
Metin SittiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.ORCID https://orcid.org/0000-0001-8249-3854

Funding

Deutscher Akademischer Austauschdienst (DAAD)Max Planck Society
6 · The paper itself

Abstract

Bacterial biohybrid microrobots possess significant potential for targeted cargo delivery and minimally invasive therapy. However, many challenges, such as biocompatibility, stability, and effective cargo loading, remain. Bacterial membrane vesicles, also referred to as minicells, offer a promising alternative for creating sub-micron scale biohybrid swimmers (minicell biohybrids) due to their active metabolism, non-dividing nature, robust structure, and high cargo-carrying capacity. Here, a biohybrid system is reported that utilizes motile minicells, ≈400 nm in diameter, generated by aberrant cell division of engineered Escherichia coli (E. coli), for the first time. Achieving over 99% purification from their parental bacterial cells, minicells are functionalized with magnetic nanoparticles (MNPs) to enable external magnetic control. Minicell biohybrids are capable of swimming at an average speed of up to 13.3 µm s

Indexed as

Drug Delivery SystemsEscherichia coliDoxorubicinHumansMagnetite NanoparticlesDoxorubicinMagnetite Nanoparticlesbacterial biohybridsbacterial membrane vesiclesbacterial minicellsbiohybrid microrobotstargeted drug delivery

Identifiers

PMID40577588
PMCPMC12462955

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.