Evidence map›Paper›PMID 40577592›Full record

ArticleCardiovascular research2025

Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke.

Jordan J Lee, Hiran A Prag, Karthik Chary, Jiro Abe, Shinpei Uno, Annabel Sorby-Adams, Chak Shun Yu, Olga Sauchanka, Amin Mottahedin, Joshua D Kaggie and 3 more

Abstract read
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In one paragraph

Article in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Black gas, bright future: HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jordan J LeeDepartment of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Hiran A PragDepartment of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Karthik CharyPreclinical Imaging Suite, Anne McLaren Building, University of Cambridge, CB2 0BA, UK.
Jiro AbeDepartment of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Shinpei UnoMRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Annabel Sorby-AdamsDepartment of Neurology and the Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Chak Shun YuMRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Olga SauchankaDepartment of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Amin MottahedinNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Joshua D KaggiePreclinical Imaging Suite, Anne McLaren Building, University of Cambridge, CB2 0BA, UK.
Ferdia A GallagherPreclinical Imaging Suite, Anne McLaren Building, University of Cambridge, CB2 0BA, UK.
Michael P MurphyDepartment of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Thomas KriegDepartment of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.ORCID 0000-0002-5192-580X

Funding

British Heart Foundation PG/23/11344Medical Research Council UK MC_UU_00028/4NIHR Cambridge Biomedical Research Centre NIHR203312Wellcome TrustWellcome Trust 220257/Z/20/Z
6 · The paper itself

Abstract

aimsIschemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischemic tissue, enhancing patient outcome, compared to recombinant tissue plasminogen activator (rtPA) alone. Even so, there is still extensive brain infarction and disability following MT, which is exacerbated by ischemia-reperfusion injury (IRI) and other pathological processes during reperfusion. Hence, an adjunct therapy to MT that decreases IRI should enhance patient outcomes. METHODS AND

resultsTo test this possibility, we adapted the transient middle cerebral artery occlusion (tMCAO) mouse model to allow local intra-arterial administration of acidified disodium malonate (aDSM) to decrease IRI as the ischemic tissue was reperfused. Administration of aDSM (160 mg/kg; pH 6) during reperfusion decreased brain infarct volume by ∼60% when assessed by magnetic resonance imaging (MRI) 24 h after reperfusion and improved neurological function.

conclusionThese findings suggest aDSM as a potential adjunct therapy to further improve outcomes for stroke patients treated by MT.

Indexed as

BrainInfarction, Middle Cerebral ArteryIschemic StrokeMalonatesNeuroprotective AgentsReperfusion InjuryThrombectomyAnimalsCombined Modality TherapyDisease Models, AnimalInjections, Intra-ArterialMaleMice, Inbred C57BLRecovery of FunctionTime FactorsMalonatesmalonic acidNeuroprotective AgentsIschaemia/reperfusion injuryMalonateMCT1 transporterMechanical thrombectomyMitochondriaStroke

Identifiers

PMID40577592
PMCPMC12352302

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.