Evidence map›Paper›PMID 40578434›Full record

ReviewCurrent opinion in insect science2025

tRNA expression and modifications as critical components in the biology of blood-feeding arthropods.

Melissa Kelley, Patrick A Limbach, Joshua B Benoit

Abstract readReview
In one paragraph

Review in Current opinion in insect science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Melissa KelleyDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45211, United States. Electronic address: kelleym3@mail.uc.edu.
Patrick A LimbachDepartment of Chemistry, University of Cincinnati, Cincinnati, OH 45211, United States.
Joshua B BenoitDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45211, United States. Electronic address: joshua.benoit@uc.edu.

Funding

UPLC for Enhanced Mass Spectrometry of Modified RNAsR01GM058843 · NIGMS · UNIVERSITY OF CINCINNATI · PI LIMBACH, PATRICK A · 1999 to 2025
$5.1M
Mosquito hydration status as a mechanism that alters pre-feeding host interactions and post-feeding physiologyR01AI148551 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., XIAO, YANYU · 2020 to 2024
$2.1M
tRNA modifications as critical components of insect blood feeding and reproductionR21AI176098 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., LIMBACH, PATRICK A · 2023 to 2024
$446k
Influence of sleep-like states on mosquito behavior and physiologyR21AI166633 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., VINAUGER, CLEMENT · 2022 to 2023
$429k
NIAID NIH HHS R01 AI148551NIAID NIH HHS R21 AI166633NIAID NIH HHS R21 AI176098NIGMS NIH HHS R01 GM058843
6 · The paper itself

Abstract

Alterations to the proteome are necessary for physiological processes in blood-feeding arthropods. To account for this, transfer RNA (tRNA) levels and chemical modifications are utilized for protein synthesis. Here, we discuss an overview of tRNA regulation in blood-feeding systems. This topic expands to host-microbial interactions as tRNA modifications require micronutrients acquired from symbionts and diet. Lastly, modifications are likely involved in the molecular dynamics between vectors and pathogens, which may impact transmission to vertebrate hosts. The tRNA levels and their modifications likely play crucial roles in the tripartite interaction between mosquitoes, their microbiome, and transmissable pathogens, providing a novel target to suppress the spread of mosquito-borne diseases.

Indexed as

ArthropodsCulicidaeRNA, TransferAnimalsRNA, Transfer

Identifiers

PMID40578434
PMCPMC12680450

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.