ArticleIn vivo (Athens, Greece)
Dysregulated Pro-inflammatory and Anti-inflammatory Cytokine Responses to Microbe-associated Molecular Patterns in X-linked Chronic Granulomatous Disease.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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13 authors.
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Abstract
BACKGROUND/
aimChronic granulomatous disease (CGD) is a hereditary immune deficiency caused by mutations in nicotinamide adenine dinucleotide phosphate oxidase subunits. X-linked CGD caused by mutations in gp91 PATIENTS AND
methodsWe evaluated the cytokine and chemokine profiles in two patients with X-linked CGD. Peripheral blood mononuclear cells (PBMCs) were isolated and stimulated with various bacterial and fungal MAMPs.
resultsProduction of C-X-C motif chemokine ligand 8, interleukin-6 (IL-6), IL-10, and tumor necrosis factor-α was enhanced by PBMCs isolated from patients with X-linked CGD as compared with those from healthy controls when stimulated with bacterial and fungal MAMPs.
conclusionA dysregulated balance between pro-inflammatory and anti-inflammatory cytokines may contribute to the manifestations of recurrent infection, autoimmunity, and IBD in patients with X-linked CGD.
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