ArticleSchizophrenia bulletin2026
Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights.
Article in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Toward precision medicine: can neuroimaging prospectively predict early treatment outcomes in schizophrenia spectrum disorders? A systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Review
- Shared genetic architecture between Alzheimer's disease and brain morphology.Alzheimer's research & therapy · 2026Article
- B cell pathways implicate shared genetic architecture between schizophrenia and immune-mediated diseases.Journal of translational medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundGenetic studies have shown associations between genetic risk for schizophrenia and brain imaging phenotypes. However, prior studies focused on a single neuroimaging modality and/or employed methods that do not fully elucidate the shared genetic architecture between them, limiting our understanding of their complex genetic relationship. STUDY
designWe used genome-wide association study summary statistics for schizophrenia alongside 37 brain measurements, selected based on adequate SNP-based heritability and representing structural, microstructural, and functional brain features derived from T1, diffusion tensor imaging (DTI), and resting-state functional magnetic resonance imaging (rs-fMRI). These were integrated with a clinical cohort (1065 cases, 1037 controls) to examine the polygenic overlap between schizophrenia and brain measurements. Polygenic overlap was assessed at genome-wide and individual locus levels through linkage disequilibrium score regression, polygenic scoring (PGS), bivariate MiXeR, and conjunctional false discovery rate. STUDY
resultsSchizophrenia showed weak genetic correlations with all brain measures (rg = -0.131 to 0.146; PFDR = .069 to .019), and no significant correlation with brain PGS. Nonetheless, a substantial proportion of causal variants with mixed effect direction were shared between schizophrenia and brain traits. Genetic correlations and polygenic scores showed significant positive associations with the proportion of shared variants with concordant effect direction. Additionally, we identified 218 loci shared with schizophrenia in T1, 138 in DTI, and 24 in rs-fMRI measures.
conclusionsOur findings indicate shared genetic underpinnings between schizophrenia and brain structure and functional connectivity, emphasizing the necessity for complementary methodologies to investigate the genetic overlap between complex polygenic traits.
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