Evidence mapPaperPMID 40579405Full record

ArticleScientific reports2025

Synthesis of Chitosan based nanoemulsions and their characterization and antifungal activity toward fungi causing mucormycosis.

Mohamed S Hasanin, Fathallah A Ayoob, Amr H Hashem, Mahmoud Emam

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohamed S HasaninCellulose & Paper Department, National Research Centre, El-Buhouth St., Dokki, 12622, Egypt.
Fathallah A AyoobChemical industries Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.
Amr H HashemBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, 11884, Egypt. amr.hosny86@azhar.edu.eg.
Mahmoud EmamPhytochemistry and Plant Systematics Department, National Research Centre, Dokki, Giza, 12622, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aromatic plants produce essential oils (EOs) with diverse phytochemicals and biological applications. This study investigated three eco-friendly nanoemulsions of Lemon peel (LPO), Turmeric (TO), and Black seed (BSO) oils loaded into nanochitosan (NCh) for their antifungal activity against resistant fungal strains. Phytochemical analysis identified oxygenated/non-oxygenated hydrocarbons and saturated/unsaturated fatty acids in the EOs. Physicochemical characterization using FTIR, DLS, and HR-TEM showed stable nanoemulsions and nanochitosan with homogeneous particle size distributions in the nanoscale range. Notably, the essential oil nanoemulsions exhibited potent antifungal activity against Mucor racemosus, Rhizopus microsporus, and Lichtheimia corymbifera, resistant to commercial antifungal drugs. The nanoemulsions loaded with 1-3% chitosan showed inhibition zones ranging from 17 to 23 mm, outperforming the synthetic antifungal treatments. These findings highlight the potential of plant-derived essential oil nanoemulsions loaded into biocompatible nanochitosan as a promising, sustainable alternative to combat the growing threat of invasive fungal infections and drug resistance. Incorporating natural, eco-friendly materials enhances the stability, bioavailability, and targeted delivery of the active phytochemicals, contributing to the antifungal solution's overall efficacy and safety profile.

Indexed as

Antifungal AgentsChitosanMucormycosisCurcumaEmulsionsMicrobial Sensitivity TestsMucorNanoparticlesOils, VolatilePlant OilsRhizopusAntifungal AgentsChitosanEmulsionsOils, VolatilePlant OilsAntifungal activityFungal infectionMucormycosisNanochitosanNanoemulsionPhytochemical analysis

Identifiers

PMID40579405
PMCPMC12205050

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.