Evidence map›Paper›PMID 40579541›Full record

ArticleCommunications biology2025

Structural insights into ligand recognition and G protein preferences across histamine receptors.

Yuma Matsuzaki, Fumiya K Sano, Hidetaka S Oshima, Hiroaki Akasaka, Kazuhiro Kobayashi, Tatsuki Tanaka, Yuzuru Itoh, Wataru Shihoya, Yoshiaki Kise, Tsukasa Kusakizako and 2 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuma MatsuzakiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2545-233X
Fumiya K SanoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan. 08082660s13@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-8965-788X
Hidetaka S OshimaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0009-0000-0341-707X
Hiroaki AkasakaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2118-0912
Kazuhiro KobayashiResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3366-3586
Tatsuki TanakaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5728-7573
Yuzuru ItohDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7802-5572
Wataru ShihoyaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4813-5740
Yoshiaki KiseDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1840-5028
Tsukasa KusakizakoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6186-6647
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan. iaska@tohoku.ac.jp.ORCID http://orcid.org/0000-0003-0805-4049
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0003-1813-7008

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05037MEXT | JST | Core Research for Evolutional Science and Technology (CREST) JPMJCR20E2
6 · The paper itself

Abstract

Histamine exerts critical physiological roles by activating four receptor subtypes, each exhibiting a specific G protein preference. Among these, the histamine H

Indexed as

GTP-Binding ProteinsReceptors, HistamineReceptors, Histamine H1Receptors, Histamine H4AnimalsCryoelectron MicroscopyHEK293 CellsHistamineHumansLigandsModels, MolecularProtein BindingProtein ConformationGTP-Binding ProteinsHistamineLigandsReceptors, HistamineReceptors, Histamine H1Receptors, Histamine H4

Identifiers

PMID40579541
PMCPMC12205060

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.