ArticleNature immunology2025
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Article
- PRMT7 restricts CD8+ T cells expansion via the NF-ΚB pathway.Nature communications · 2026Article
- Nanozyme-Mediated Cellular and Microenvironmental Metabolic Reprogramming for Boosting Cancer Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Autophagy Orchestrates Anti-Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP-2 Axis in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immunological and prognostic impact of NRF2 in high grade serous ovarian cancer.Genes and immunity · 2026Article
- Nrf2-mediated metabolic reprogramming drives regulatory T cell accumulation in hepatocellular carcinoma.Nature communications · 2026Article
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Transcription factor collaboration enables precise T cell state engineering.bioRxiv : the preprint server for biology · 2026Article
- Metabolomics Reveals Potential Biomarkers for Early Detection of irAEs in ICI-Treated Patients.Drug design, development and therapy · 2026Article
- Redox-metabolic circuits as a central regulator of T cell-based immunotherapy.Frontiers in immunology · 2026Review
- Hot-yet-suppressed under PD-1 blockade: an RMP-NRF2-PD-L1 axis associated with a reduced proportional response in hepatocellular carcinoma.Frontiers in immunology · 2026Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Integrating T cell signaling and metabolism to enhance T cell engager responses in solid tumors.Frontiers in immunology · 2026Review
- Cisformer: a scalable cross-modality generation framework for decoding transcriptional regulation at single-cell resolution.Genome biology · 2025Article
- NRF2 immunobiology in cancer: implications for immunotherapy and therapeutic targeting.Oncogene · 2025Review
- In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors.bioRxiv : the preprint server for biology · 2025Article
- Nrf2 drives activation-driven expansion of CD4Cell reports · 2025Article
- Lipids rewire T cell exhaustion.Nature immunology · 2025Article
- A CD4Immunity · 2025Article
Corrections and comments
- Update of
Authors and funding
20 authors.
Michael S DahabiehDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Lisa M DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Brandon M OswaldDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Susan M Kitchen-GoosenDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Zhen FuBioinformatics and Biostatistics Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Matthew VosDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Shelby E ComptonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Joseph LongoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-9580-5105
Nicole M FoyDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Kelsey S WilliamsDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-4163-5075
Abigail E EllisMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-8736-8283
Amy JohnsonMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Ibukunoluwa SodiyaDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0009-0000-7174-0987
Michael VincentDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Hyoungjoo LeeDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Chen YaoDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-6852-5661
Tuoqi WuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4003-1034
Ryan D SheldonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-1573-9719
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA. russell.jones@vai.org.ORCID http://orcid.org/0000-0003-2250-4675
Funding
Ketone Body Metabolism in CD8+ T Cell ResponsesR01AI165722 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI JONES, RUSSELL GRAHAM · 2022 to 2025
$3.3MProgram stem-like CD8 T cells to enhance antiviral immunity against chronic viral infectionR01AI158294 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Tuoqi Wu · 2022 to 2026
$2.9MHarnessing Stem-Like CD8 T Cells for Immunotherapies to Eradicate HIV ReservoirsDP2AI154450 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI YAO, CHEN · 2021 to 2025
$2.5MRejuvenating aged T cell immunity by targeting stem cell-like CD8 T cellsR00AG056524 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WU, TUOQI · 2019 to 2021
$733kChromatin architecture as a determinant of dendritic cell functionR21AI153997 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI KRAWCZYK, CONNIE · 2020 to 2021
$523kCancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RR210035Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MFE-181903Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MFE-403514NIAID NIH HHS DP2 AI154450NIAID NIH HHS R01 AI158294NIAID NIH HHS R01 AI165722NIAID NIH HHS R21 AI153997NIA NIH HHS K99 AG056524NIA NIH HHS R00 AG056524U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI154450U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI158294U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI153997U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG056524
Abstract
CD8
Indexed as
CD8-Positive T-LymphocytesNF-E2-Related Factor 2AnimalsHumansKelch-Like ECH-Associated Protein 1MiceMice, Inbred C57BLMice, KnockoutOxidative StressSignal TransductionT-Cell ExhaustionKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.